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首页> 外文期刊>Trends in Neurosciences >Cajal-Retzius cells and the development of the neocortex.
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Cajal-Retzius cells and the development of the neocortex.

机译:Cajal-Retzius细胞和新皮层的发育。

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摘要

The dual origin, structural organization, and evolving ascending stratification of the mammalian neocortex are explored from a developmental perspective. Layer I and subplate (layer VII) zone of the neocortex evolve first from a primordial plexiform neuropil that is established throughout the non-olfactory telencephalon and that is common to amphibians, reptiles and mammals.The remaining laminations (strata) of the neocortex evolve later, between layer I and the subplate zone, from the cortical plate (CP), which represents a multilayered mammalian evolutionary feature. The attraction of CP neurons towards layer I, their progressive ascending (inside-out) placement, common early differentiation stage (regardless of size, location, cortical depth, or eventual functional role, or all of these), and the unique morphologic features of its pyramidal neuron are developmental processes controlled by layer I and its Cajal-Retzius cells. Based on the role of these early neurons and of layer I, a new theory of neocortical cytoarchitectonics and nomenclature is proposed to explain the basic structural and functional organization of the mammalian neocortex, the morphology of its pyramidal cells, and the addition of new pyramidal cell strata that characterize its phylogenetic evolution.
机译:从发展的角度探讨了哺乳动物新皮层的双重起源,结构组织和进化上的分层。新皮质的第I层和亚板区(VII层)首先从原始的丛状神经纤维进化而来,该原始神经丛在整个非嗅觉性端脑中建立,并且是两栖动物,爬行动物和哺乳动物所共有的。在第I层和亚板区之间,来自皮质板(CP),代表多层哺乳动物的进化特征。 CP神经元对I层的吸引力,其进行性升序(由内而外)放置,常见的早期分化阶段(无论大小,位置,皮质深度或最终的功能角色,或所有这些),以及它们的独特形态特征它的锥体神经元是由第一层及其Cajal-Retzius细胞控制的发育过程。基于这些早期神经元和第一层的作用,提出了新的新皮层细胞结构学和命名学说,以解释哺乳动物新皮层的基本结构和功能组织,其锥体细胞的形态以及新锥体细胞的添加表征其系统发育演化的地层。

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