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首页> 外文期刊>Transplantation: Official Journal of the Transplantation Society >Normalization of diabetes by xenotransplantation of cryopreserved microencapsulated pancreatic islets. Application of a new strategy in islet banking.
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Normalization of diabetes by xenotransplantation of cryopreserved microencapsulated pancreatic islets. Application of a new strategy in islet banking.

机译：通过冷冻保存的微囊化胰岛的异种移植使糖尿病正常化。新策略在胰岛银行业务中的应用。

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摘要

To develop a requisite islet bank for the clinical implementation of an injectable bioartificial endocrine pancreas, microencapsulated islets were cryopreserved and assessed both in vitro by static glucose challenge and in a transplantation study. The insulin response of cryopreserved encapsulated rat islets was comparable with fresh islets. Transplantation of 800-900 banked rat islets resulted in the normalization of the metabolic blood glucose perturbation, body weight, and general health characteristics in 8 out of 8 diabetic mice for the study duration of 90 days. Whereas free islets are easily fragmented and lost during the freezing process, the capsule protects the fragile islets from freezing damage, increasing the retrieval rate from 79.5 +/- 9.8% to 97.2 +/- 1.3.
机译：为了开发可注射的生物人工内分泌胰腺的临床实施所需的胰岛库，将微囊化的胰岛冷冻保存并在体外通过静态葡萄糖激发和移植研究进行评估。冷冻保存的胶囊化大鼠胰岛的胰岛素反应与新鲜胰岛相当。在研究持续90天的过程中，对8只糖尿病小鼠中的8只，将800-900只围成的大鼠小岛进行了移植，从而使代谢血糖扰动，体重和一般健康特征正常化。尽管游离的胰岛在冷冻过程中很容易碎裂和丢失，但胶囊可保护脆弱的胰岛不受冷冻损害，将回收率从79.5 +/- 9.8％提高到97.2 +/- 1.3。

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