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首页> 外文期刊>Value in health: the journal of the International Society for Pharmacoeconomics and Outcomes Research >Relationship between health-related quality of life, pain, and functional disability in neuropathic pain patients with failed back surgery syndrome.
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Relationship between health-related quality of life, pain, and functional disability in neuropathic pain patients with failed back surgery syndrome.

机译：背部手术综合征失败的神经性疼痛患者与健康相关的生活质量，疼痛和功能障碍之间的关系。

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OBJECTIVES: Patients with failed back surgery syndrome (FBSS) and chronic neuropathic pain experience levels of health-related quality of life (HRQoL) that are considerably lower than those reported in other areas of chronic pain. The aim of this article was to quantify the extent to which reductions in (leg and back) pain and disability over time translate into improvements in generic HRQoL as measured by the EuroQoL-5D and SF-36 instruments. METHODS: Using data from the multinational Prospective, Randomized, Controlled, Multicenter Study of Patients with Failed Back Surgery Syndrome trial, we explore the relationship between generic HRQoL--assessed using two instruments often used in clinical trials (i.e., the SF-36 and EuroQol-5D)--and disease-specific outcome measures (i.e., Oswestry disability index [ODI], leg and back pain visual analog scale [VAS]) in neuropathic patients with FBSS. RESULTS: In our sample of 100 FBSS patients, generic HRQoL was moderately associated with ODI (correlation coefficient: -0.462 to -0.638) and mildly associated with leg pain VAS (correlation coefficient: -0.165 to -0.436). The multilevel regression analysis results indicate that functional ability (as measured by the ODI) is significantly associated with HRQoL, regardless of the generic HRQoL instrument used. On the other hand, changes over time in leg pain were significantly associated with changes in the EuroQoL-5D and physical component summary scores, but not with the mental component summary score. CONCLUSIONS: Reduction in leg pain and functional disability is statistically significantly associated with improvements in generic HRQoL. This is the first study to investigate the longitudinal relationship between generic and disease-specific HRQoL of neuropathic pain patients with FBSS, using multinational data.
机译：目标：背部手术失败综合征（FBSS）和慢性神经性疼痛患者的健康相关生活质量（HRQoL）水平明显低于其他慢性疼痛领域。本文的目的是量化通过EuroQoL-5D和SF-36仪器测得的随着时间的推移，（腿和背部）疼痛和残疾的减轻转化为通用HRQoL改善的程度。方法：使用来自多国前瞻性，随机，对照，多中心研究的失败的背部手术综合征患者试验的数据，我们探索了通用HRQoL之间的关系-使用两种临床试验中常用的仪器进行了评估（即SF-36和EuroQol-5D）以及针对神经性FBSS患者的疾病特定结局指标（例如，Oswestry残疾指数[ODI]，腿和背痛视觉模拟量表[VAS]）。结果：在我们的100名FBSS患者样本中，通用HRQoL与ODI呈中度相关（相关系数：-0.462至-0.638），与腿痛VAS呈中度相关（相关系数：-0.165至-0.436）。多级回归分析结果表明，功能能力（通过ODI衡量）与HRQoL显着相关，而与所使用的通用HRQoL仪器无关。另一方面，腿部疼痛随时间的变化与EuroQoL-5D和身体成分的总评分的变化显着相关，而与精神成分的总评分却没有关系。结论：统计学上，腿痛和功能障碍的减轻与通用HRQoL的改善显着相关。这是第一项使用跨国数据研究神经性疼痛性FBSS患者的通用和特定疾病HRQoL之间的纵向关系的研究。

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