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首页> 外文期刊>Trends In Parasitology >Intracellular protozoan parasites and apoptosis: diverse strategies to modulate parasite-host interactions
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Intracellular protozoan parasites and apoptosis: diverse strategies to modulate parasite-host interactions

机译:细胞内原生动物寄生虫和细胞凋亡:调节寄生虫-宿主相互作用的多种策略

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摘要

Programmed cell death (apoptosis) is an important regulator of the host's response during infection with a variety of intracellular protozoan parasites. Parasitic pathogens have evolved diverse strategies to induce or inhibit host-cell apoptosis, thereby modulating the host's immune response, aiding dissemination within the host or facilitating intracellular survival. Here, we review the molecular and cell-biological mechanisms of the pathogen-induced modulation of host-cell apoptosis and its effects on the parasite-host interaction and the pathogenesis of parasitic diseases. We also discuss the previously unrecognized phenomenon of apoptotic cell death in (unicellular) protozoan parasites and its potential implications.
机译:程序性细胞死亡(细胞凋亡)是感染各种细胞内原生动物寄生虫期间宿主反应的重要调节剂。寄生性病原体已经进化出多种策略来诱导或抑制宿主细胞凋亡,从而调节宿主的免疫反应,帮助宿主内传播或促进细胞内存活。在这里,我们审查了病原体诱导的宿主细胞凋亡调节的分子和细胞生物学机制及其对寄生虫-宿主相互作用和寄生虫病发病机制的影响。我们还讨论了(单细胞)原生动物寄生虫中凋亡细胞死亡的先前未被认识的现象及其潜在影响。

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