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首页> 外文期刊>Veterinary Anaesthesia and Analgesia >Effects of tramadol alone, in combination with meloxicam or dipyrone, on postoperative pain and the analgesic requirement in dogs undergoing unilateral mastectomy with or without ovariohysterectomy.
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Effects of tramadol alone, in combination with meloxicam or dipyrone, on postoperative pain and the analgesic requirement in dogs undergoing unilateral mastectomy with or without ovariohysterectomy.

机译：单独使用曲马多联合美洛昔康或双嘧啶对接受单侧乳房切除术或不进行卵巢子宫切除术的狗的术后疼痛和镇痛要求的影响。

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Objective: To compare the effects of tramadol alone, or in combination with dipyrone or meloxicam, on postoperative pain and analgesia requirement after unilateral mastectomy with or without ovariohysterectomy in dogs. Study design: Prospective, randomized, clinical study. Animals: Twenty seven bitches undergoing unilateral mastectomy with or without ovariohysterectomy. Methods: Anesthesia was induced with propofol and maintained with isoflurane and a constant rate infusion of morphine. Before the end of surgery, dogs were randomly assigned to receive intravenous tramadol alone (3 mg kg-1, group T), combined with dipyrone (30 mg kg-1, group TD) or meloxicam (0.2 mg kg-1, group TM). Dogs received additional doses of tramadol (groups T and TM) or tramadol with dipyrone (group TD) at 8 and 16 hours after extubation. Postoperative pain was assessed by a blinded observer before anesthesia (baseline) and at 1, 2, 3, 4, 6, 8, 12, 16 and 24 hours after extubation using a visual analog scale (VAS) and a modified Glasgow scale. Rescue analgesia (morphine, 0.5 mg kg-1) was administered if the Glasgow pain score was >3.5. Results: There were no significant differences among groups in pain scores evaluated by the VAS or the Glasgow scale. In groups T, TD and TM, pain scores were significantly higher than at baseline for 6, 8 and 2 hours, respectively. Rescue analgesia was administered to 3/9, 2/9 and 1/9 dogs in groups T, TD and TM, respectively (p>0.05) [Correction added on 15 August 2013, after first online publication: 'T, TM and TD' was changed to 'T, TD and TM'.]. Conclusions and clinical relevance: Under the conditions of this study, tramadol alone or in combination with dypyrone or meloxicam provided effective analgesia for 24 hours in most dogs after unilateral mastectomy with or without ovariohysterectomy. Further evaluation of combination therapies is needed in larger groups of dogs.
机译：目的：比较曲马多单独使用或与双嘧啶或美洛昔康联合使用对犬单侧乳房切除术或不进行卵巢子宫切除术后术后疼痛和镇痛的作用。研究设计：前瞻性，随机，临床研究。动物：二十七只母犬接受单侧乳房切除术或不进行卵巢子宫切除术。方法：用异丙酚诱导麻醉，并用异氟烷和吗啡恒速输注维持麻醉。在手术结束前，将狗随机分配为单独接受静脉曲马多（3 mg kg -1 ，T组）联合双嘧啶（30 mg kg -1 ）， TD组）或美洛昔康（0.2 mg kg -1 ，TM组）。拔管后8小时和16小时，狗接受额外剂量的曲马多（T和TM组）或曲潘多与潘生酮（TD组）。盲人观察者在麻醉前（基线）以及拔管后的1、2、3、4、6、8、12、16和24小时使用视觉模拟量表（VAS）和改良的格拉斯哥量表评估术后疼痛。如果格拉斯哥的疼痛评分> 3.5，则进行抢救性镇痛（吗啡，0.5 mg kg -1 ）。结果：通过VAS或格拉斯哥量表评估的疼痛评分在各组之间无显着差异。在T，TD和TM组中，分别在6、8和2小时内，疼痛评分显着高于基线。 T，TD和TM组分别对3 / 9、2 / 9和1/9狗施行了急救镇痛（p> 0.05）[2013年8月15日，首次在线发表后修正为：'T，TM和TD ”更改为“ T，TD和TM”。]。结论与临床意义：在这项研究的条件下，曲马多单独使用或与吡喃酮或美洛昔康联合使用可对大多数犬进行单侧乳房切除术或不进行卵巢子宫切除术后提供24小时的有效镇痛作用。在较大的狗群中，需要进一步评估组合疗法。

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