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首页> 外文期刊>Veterinary Anaesthesia and Analgesia >The effect of the novel alpha-2-adrenoceptor agonist naphthylmedetomidine on pulse rate, arterial blood pressure and sedation in rabbits
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The effect of the novel alpha-2-adrenoceptor agonist naphthylmedetomidine on pulse rate, arterial blood pressure and sedation in rabbits

机译：新型α-2-肾上腺素受体激动剂萘基美托咪定对家兔脉搏，动脉血压和镇静作用的影响

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OBJECTIVE: The aim of this study was to investigate the effect of a novel alpha-2-adrenoceptor (alpha(2)-AR) agonist, naphthylmedetomidine, on cardiorespiratory function and sedation in rabbits in comparison with medetomidine. STUDY DESIGN: Prospective, randomized, experimental trial. ANIMALS: Forty-two chinchilla rabbits of both sexes, weighing 2.5-4.5 kg. METHODS: The rabbits received 350 microg kg(-1) naphthylmedetomidine (n = 21) or medetomidine (n = 21) intramuscularly according to a randomization scheme. Arterial blood pressure (AP), oxygen saturation of haemoglobin (SpO(2)), pulse rate (PR) and righting reflex were monitored for 20 minutes after injection. RESULTS: Both drugs significantly decreased PR. The effect of medetomidine was significantly greater than that of naphthylmedetomidine and was evident within 1 minute. The decrease in PR after naphthylmedetomidine administration first appeared after 4 minutes. Medetomidine decreased the SpO(2) after 3 minutes but there was no effect after naphthylmedetomidine. Medetomidine decreased the mean, systolic and diastolic AP within 5 minutes of administration but naphthylmedetomidine had no effect. The mean time to loss of righting reflex was 185 and 714 seconds after the administration of medetomidine and naphthylmedetomidine respectively. CONCLUSIONS AND CLINICAL RELEVANCE: These results provide the first description of the effects of naphthylmedetomidine on cardiovascular and psychomotor functions in rabbits. Further work is required to reveal the anaesthetic sparing, analgesic or sedative effect of partial naphthylmedetomidine.
机译：目的：本研究的目的是与美托咪定相比，研究一种新型的α-2-肾上腺素受体（α（2）-AR）激动剂萘基美托咪定对家兔心肺功能和镇静作用的影响。研究设计：前瞻性，随机试验。动物：42只雄性兔子，体重2.5-4.5公斤。方法：根据随机分配方案，兔肌肉内注射350微克kg（-1）萘基美托咪定（n = 21）或美托咪定（n = 21）。注射后20分钟监测动脉血压（AP），血红蛋白氧饱和度（SpO（2）），脉搏率（PR）和扶正反射。结果：两种药物均显着降低PR。美托咪定的作用明显大于萘美托咪定的作用，并且在1分钟内就很明显。萘基美托咪定首次给药后4分钟后出现PR下降。美托咪定在3分钟后降低了SpO（2），但萘基美托咪定后没有作用。美托咪定在给药后5分钟内降低了平均，收缩期和舒张期AP，但萘基美托咪定没有作用。给予美托咪定和萘基美托咪啶后，失去正直反射的平均时间分别为185和714秒。结论和临床意义：这些结果首次描述了萘基美托咪定对家兔心血管和精神运动功能的影响。需要进一步的工作来揭示部分萘基美托咪定的麻醉作用，镇痛或镇静作用。

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