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首页> 外文期刊>Veterinary Anaesthesia and Analgesia >Anaesthesia with a combination of ketamine and medetomidine in the rabbit: effect of premedication with buprenorphine
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Anaesthesia with a combination of ketamine and medetomidine in the rabbit: effect of premedication with buprenorphine

机译：氯胺酮和美托咪定联合对兔的麻醉作用：丁丙诺啡前药的作用

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To assess the effects of premedication with buprenorphine on the characteristics of anaesthesia induced with ketamine/medetomidine. Prospective crossover laboratory study. Six female New Zealand White rabbits. Rabbits received, on occasions separated by 7 days, either buprenorphine (0.03 mg kgp#) or saline subcutaneously (SC) as premedication, followed 1 hour later by SC ketamine (15 mg kgp#) and medetomidine (0.25 mg kgp#) (K/M). At pre-determined time points reflex responses and cardiopulmonary parameters were recorded and arterial blood samples taken for analysis. Total sleep time was the duration of loss of the righting reflex. Duration of surgical anaesthesia was the time of suppression of the ear pinch and pedal withdrawal reflexes. Wilcoxon signed-ranks tests were used to compare data before (T) and 10 minutes after (T) injection with K/M. All animals lost all three reflex responses within 10 minutes of injection of K/M. The duration of loss of these reflexes significantly increased in animals that received buprenorphine. At induction, animals that had received buprenorphine tended to have a lower respiration rate but there were no significant differences in arterial PCO, PO or pH between treatments. Hypoxaemia [median PaO < 6.0 kPa (45 mmHg)] developed in both treatments at T but there was no significant difference between treatments. Mean arterial pressure (MAP) was lower at T in animals that had received buprenorphine. Premedication with buprenorphine significantly increased the duration of anaesthesia induced by K/M, with no significant depression of respiration further to the control treatment within the first 10 minutes of anaesthesia. The MAP decreased but this was not reflected in a difference in other physiological parameters. These data show that premedication with buprenorphine, before K/M anaesthesia in the rabbit, has few negative effects and may provide beneficial analgesia.
机译：评估丁丙诺啡前药对氯胺酮/美托咪定诱导的麻醉特性的影响。前瞻性交叉实验室研究。六只雌性新西兰白兔。间隔7天时，兔子接受丁丙诺啡（0.03 mg kgp＃）或皮下注射生理盐水（SC）进行预用药，然后在1小时后接受SC氯胺酮（15 mg kgp＃）和美托咪定（0.25 mg kgp＃）（K / M）。在预定的时间点记录反射反应和心肺参数，并采集动脉血样本进行分析。总睡眠时间是指失去正直反射的持续时间。手术麻醉的持续时间为抑制耳捏和踏板撤回反射的时间。使用Wilcoxon符号秩检验比较K / M注射前（T）和（T）后10分钟的数据。在注射K / M的10分钟内，所有动物都失去了所有三种反射反应。在接受丁丙诺啡的动物中，这些反射丧失的持续时间显着增加。诱导时，接受丁丙诺啡的动物的呼吸频率趋于降低，但治疗之间的动脉PCO，PO或pH值无显着差异。两种疗法在T均出现低氧血症[中位数PaO <6.0 kPa（45 mmHg）]，但两种疗法之间无显着差异。在接受丁丙诺啡的动物中，T处的平均动脉压（MAP）较低。丁丙诺啡的预用药显着增加了K / M诱导的麻醉持续时间，并且在麻醉的前10分钟内，与对照治疗相比，没有明显的呼吸抑制。 MAP降低，但是这没有反映在其他生理参数的差异中。这些数据表明，在兔子进行K / M麻醉之前，使用丁丙诺啡进行预用药几乎没有不良反应，并且可以提供有益的镇痛作用。

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