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首页> 外文期刊>Veterinary Anaesthesia and Analgesia >Effect of intravenous propofol and remifentanil on heart rate, blood pressure and nociceptive response in acepromazine premedicated dogs.
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Effect of intravenous propofol and remifentanil on heart rate, blood pressure and nociceptive response in acepromazine premedicated dogs.

机译：静脉注射丙泊酚和瑞芬太尼对醋丙嗪治疗的狗的心律，血压和伤害反应的影响。

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Objective: To investigate the cardiorespiratory, nociceptive and endocrine effects of the combination of propofol and remifentanil, in dogs sedated with acepromazine. Study design: Prospective randomized, blinded, cross-over experimental trial. Animals: Twelve healthy adult female cross-breed dogs, mean weight 18.4+or-2.3 kg. Methods: Dogs were sedated with intravenous (IV) acepromazine (0.05 mg kg-1) followed by induction of anesthesia with IV propofol (5 mg kg-1). Anesthesia was maintained with IV propofol (0.2 mg kg-1 minute-1) and remifentanil, infused as follows: R1, 0.125 micro g kg-1 minute-1; R2, 0.25 micro g kg-1 minute-1; and R3, 0.5 micro g kg-1 minute-1. The same dogs were administered each dose of remifentanil at 1-week intervals. Heart rate (HR), mean arterial pressure (MAP), respiratory rate (fR), end tidal CO2 (PE'CO2), arterial hemoglobin O2 saturation, blood gases, and rectal temperature were measured before induction, and 5, 15, 30, 45, 60, 75, 90, and 120 minutes after beginning the infusion. Nociceptive response was investigated by electrical stimulus (50 V, 5 Hz and 10 ms). Blood samples were collected for plasma cortisol measurements. Statistical analysis was performed by ANOVA (p<0.05). Results: In all treatments, HR decreased during anesthesia with increasing doses of remifentanil, and increased significantly immediately after the end of infusion. MAP remained stable during anesthesia (72-98 mmHg). Antinociception was proportional to the remifentanil infusion dose, and was considered satisfactory only with R2 and R3. Plasma cortisol concentration decreased during anesthesia in all treatments. Recovery was smooth and fast in all dogs. Conclusions and clinical relevance: Infusion of 0.25-0.5 micro g kg-1 minute-1 remifentanil combined with 0.2 mg kg-1 minute-1 propofol produced little effect on arterial blood pressure and led to a good recovery. The analgesia produced was sufficient to control the nociceptive response applied by electrical stimulation, suggesting that it may be appropriate for performing surgery.
机译：目的：研究丙泊酚和瑞芬太尼联合使用对丙氨嗪镇静的犬的心肺，伤害和内分泌作用。研究设计：前瞻性随机，双盲，交叉实验研究。动物：十二只健康的成年雌性杂交狗，平均体重18.4+或-2.3公斤。方法：给犬静脉注射醋丙嗪（0.05 mg kg -1 ），然后静脉注射异丙酚（5 mg kg -1 ）麻醉。静脉注射异丙酚（0.2 mg kg -1 分钟 -1 ）和瑞芬太尼维持麻醉，R1，0.125 micro g kg -1 分钟 -1 ; R2，0.25微克kg -1 分钟 -1 ;和R3，0.5微克kg -1 分钟 -1 。相同的狗每隔1周服用一次瑞芬太尼。心率（HR），平均动脉压（MAP），呼吸频率（f R ），潮气末CO 2 （PE'CO 2 ），在诱导前和开始输注后第5、15、30、45、60、75、90和120分钟测量动脉血红蛋白O 2 饱和度，血气和直肠温度。通过电刺激（50 V，5 Hz和10 ms）研究伤害感受反应。收集血样用于血浆皮质醇测量。通过ANOVA（ p <0.05）进行统计分析。结果：在所有治疗中，随着麻醉剂量瑞芬太尼的增加，HR下降，并且在输注结束后立即显着增加。麻醉期间MAP保持稳定（72-98 mmHg）。抗伤害感受与瑞芬太尼输注剂量成正比，并且被认为仅对R2和R3令人满意。在所有治疗过程中，血浆皮质醇浓度均下降。所有狗的恢复平稳，快速。结论和临床意义：瑞米芬太尼0.25-0.5微克kg -1 分钟 -1 分钟瑞芬太尼联合0.2 mg kg -1 分钟 -1 异丙酚对动脉血压影响不大，恢复良好。产生的镇痛作用足以控制电刺激施加的伤害性反应，表明它可能适合进行手术。

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