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首页> 外文期刊>Veterinary Immunology and Immunopathology >Use of the nitroblue tetrazolium reduction test for the evaluation ofTI Use of the nitroblue tetrazolium reduction test for the evaluation of Domperidone effects on the neutrophilic function of healthy dogs
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Use of the nitroblue tetrazolium reduction test for the evaluation ofTI Use of the nitroblue tetrazolium reduction test for the evaluation of Domperidone effects on the neutrophilic function of healthy dogs

机译：硝基蓝四唑还原试验在TI评估中的应用硝基蓝四唑还原试验在多潘立酮对健康犬中性粒细胞功能的影响的评估中的应用

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摘要

The nitroblue tetrazolium reduction test (NBT) is an assay based on the activation percentage of neutrophils in peripheral blood, that has been proposed for the follow up of canine leishmaniosis owing to the narrow relationship between the molecules involved in the oxidative burst and the leishmanicidal activity of phagocytes. Domperidone is a drug used for the treatment of canine leishmaniosis having been claimed to stimulate the dogs' cell-mediated immune response. The aim of this study was to evaluate the degree and the lasting of phagocytic activation induced by a 30-day course treatment with Domperidone (0.5 mg/kg/day) in healthy dogs, by using the NBT. A statistically significant increase in the percentages of activated phagocytes was observed in the treated group during treatment, thereafter remaining high for up to one month after the end of treatment. In contrast, untreated dogs maintained the baseline percentage of activated neutrophils all along the study. It is concluded that the NBT is a useful tool for the follow up of the stimulating effects of Domperidone on the neutrophilic response of healthy dogs and that these effects persist for up to one month after treatment with this molecule
机译：硝基蓝四唑鎓还原试验（NBT）是一种基于外周血中性粒细胞活化百分比的测定法，由于涉及到氧化性爆裂的分子与杀菌活性之间的关系狭窄，因此已建议用于犬利什曼病的随访吞噬细胞。多潘立酮是一种用于治疗犬利什曼病的药物，据称可刺激狗的细胞介导的免疫反应。这项研究的目的是通过使用NBT评估健康犬中多潘立酮（0.5 mg / kg /天）的30天疗程治疗诱导的吞噬激活的程度和持续时间。在治疗期间，在治疗组中观察到活化吞噬细胞百分比的统计学显着增加，此后在治疗结束后的一个月内一直保持高水平。相反，在整个研究过程中，未经治疗的狗保持了活化中性粒细胞的基线百分比。结论是，NBT是跟踪多潘立酮对健康犬中性粒细胞反应的刺激作用的有用工具，并且使用该分子治疗后这些作用持续长达一个月

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