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首页> 外文期刊>Veterinary Immunology and Immunopathology >Comparative study of the biochemical properties of proteasomes in domestic animals
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Comparative study of the biochemical properties of proteasomes in domestic animals

机译：家畜蛋白酶体生化特性的比较研究

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摘要

Information on the biochemical properties of proteasomes is lacking or, at best, only fragmentary for most species of veterinary interest. Moreover, direct comparison of the limited data available on the enzymatic features of proteasomes in domestic animals is rendered difficult due to the heterogeneity of the experimental settings used. This represents a clear drawback in veterinary research, given the crucial involvement of proteasomes in control of several physiological and pathological processes. We performed the first comparative analysis of key biochemical properties of proteasomes obtained from 8 different domestic mammals. Specifically, we investigated the three main peptidase activities of constitutive and immunoproteasomes in parallel and systematically checked the sensitivity of the chymotryptic site to three of the most potent and selective inhibitors available. Overall, there was substantial similarity in the enzymatic features of proteasomes among the species examined, although some interesting species-specific features were observed. (C) 2015 Elsevier B.V. All rights reserved.
机译：缺乏蛋白酶体生化特性的信息，或者对于大多数感兴趣的动物物种，充其量只是零碎的信息。此外，由于所使用的实验设置的异质性，很难对家畜中蛋白酶体的酶学特征进行有限的数据直接比较。鉴于蛋白酶体在控制几个生理和病理过程中的关键作用，这在兽医研究中代表了明显的缺陷。我们对从8种不同的家养哺乳动物获得的蛋白酶体的关键生化特性进行了首次比较分析。具体而言，我们平行研究了组成型和免疫蛋白酶体的三种主要肽酶活性，并系统地检查了胰凝乳蛋白酶位点对三种最有效和选择性抑制剂的敏感性。总体而言，虽然观察到了一些有趣的物种特异性特征，但在所检查的物种中蛋白酶体的酶促特征基本相似。 （C）2015 Elsevier B.V.保留所有权利。

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