Synthesis of 2-chloro-4-nitrophenyl alpha-L-fucopyranoside: a substrate for alpha-L-fucosidase (AFU)

Guofeng Gu; Yuguo Du; Hongyuan Hu; Cheng Jin

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Synthesis of 2-chloro-4-nitrophenyl alpha-L-fucopyranoside: a substrate for alpha-L-fucosidase (AFU)

机译：2-氯-4-硝基苯基α-L-岩藻糖苷的合成：α-L-岩藻糖苷酶（AFU）的底物

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An effective method to prepare the substrate of alpha-L-fucosidase (AFU) is described. Ethyl 1-thiofucoside with a free 2-OH group was used as the glycosyl donor, and there was found no self-condensed side product. The use of the HF·pyridine reagent to remove the silyl protecting group in the last step afforded a target molecule of high purity.

机译：描述了一种制备α-L-岩藻糖苷酶（AFU）底物的有效方法。具有游离的2-OH基团的乙基1-硫代葡糖苷被用作糖基供体，发现没有自缩合的副产物。在最后步骤中使用HF·吡啶试剂除去甲硅烷基保护基，得到高纯度的目标分子。

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《Carbohydrate research》 |2003年第15期|共5页
作者
Guofeng Gu; Yuguo Du; Hongyuan Hu; Cheng Jin;
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原文格式 PDF
正文语种 eng
中图分类 Q629;
关键词
alpha-L-fucosidase; hepatocellular carcinoma; glycosylation;

机译：α-L-岩藻糖苷酶;肝细胞癌;糖基化;

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专利

1. Synthesis of 2-chloro-4-nitrophenyl alpha-L-fucopyranoside: a substrate for alpha-L-fucosidase (AFU) [J] . Guofeng Gu, Yuguo Du, Hongyuan Hu, Carbohydrate research . 2003,第15期

机译：2-氯-4-硝基苯基α-L-岩藻糖苷的合成：α-L-岩藻糖苷酶（AFU）的底物
2. (Z)-N-(3-(2-Chloro-4-nitrophenyl)-4-methylthiazol-2(3H)-ylidene) Pivalamide: Synthesis and Crystal Structure [J] . Aamer Saeed, Michael Bolte Journal of Crystallization Process and Technology . 2011,第3期

机译：（Z）-N-（3-（2-氯-4-硝基苯基）-4-甲基噻唑-2（3H）-亚烷基）新酰胺：合成与晶体结构
3. alpha-L-Fucosidase from Bombyx mori has broad substrate specificity and hydrolyzes core fucosylated N-glycans [J] . Nakamura Shuntaro, Miyazaki Takatsugu, Park Enoch Y. Insect Biochemistry and Molecular Biology . 2020,第1期

机译：来自Bombyx Mori的α-L-岩藻糖酶具有宽的底物特异性，水解核心岩糖基化的N-聚糖
4. 2-Cyanoethylthio-1.3-dithiole-2-selone-new precusors in tetrathiafulvalene synthesis: tetrathiafulvalenes, incorporating 1,3,4-oxadiazole and cyanoethyl moieties [C] . G. G. Abashev, E. V. Shklyaeva, A. G. Tenishev, NATO Advanced Research Workshop on Molecular Low Dimensional and Nanostructured Materials for Advanced Applications . 2002

机译：2-氰基乙基硫胺-1.3-二硫醚-2-筛选 - 左旋甲醛合成中的新预防剂：TelthathiafulValenes，掺入1,3,4-氧代唑和氰基乙基部分
5. Part 1. Studies towards total synthesis of enfumafungin. Part 2. Synthesis of C8 to C13 building block of discodermolide. Part 3. Studies on LAH-mediated regioselective hydroalumination of homopropargyl alcohols. Part 4. Studies towards total synthesis of bielschowskysin. [D] . Zhao, Hong. 2006

机译：第1部分。对全合成恩氟马定的研究。第2部分。discodermolide的C8至C13结构单元的合成。第三部分。LAH介导的高炔丙醇的区域选择性加氢铝化研究。第4部分。全面研究Bielschowskysin。
6. Synthesis and properties of tetrathiafulvalenes bearing 6-aryl-14-dithiafulvenes [O] . Aya Yoshimura, Hitoshi Kimura, Kohei Kagawa, 2020

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7. Cloning of large DNA fragments, which hybridize with actinorhodin biosynthesis genes, from kalafungin and nanaomycin a methyl ester producers and identification of genes for kalafungin biosynthesis of the kalafungin producer. [O] . SHIZUKO KAKINUMA, YOSHIO TAKADA, HARUO IKEDA, 1991

机译：大型DNA片段的克隆，杂交与Actinorhodin生物合成基因，来自Kalafungin和Nanaomycin的甲酯生产者和Kalafungin生产者的Kalafungin生物合成的鉴定。

Synthesis of 2-chloro-4-nitrophenyl alpha-L-fucopyranoside: a substrate for alpha-L-fucosidase (AFU)

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