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首页> 外文期刊>Vascular and endovascular surgery >Evaluation of thrombogenicity by indium-111 platelet scintigraphy in endografting for abdominal aortic aneurysms.
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Evaluation of thrombogenicity by indium-111 platelet scintigraphy in endografting for abdominal aortic aneurysms.

机译：铟111血小板闪烁显像术评估腹主动脉瘤内膜移植术中的血栓形成性。

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摘要

Obstruction of the endograft limb by thrombosis has often been reported and may cause fatal complications such as leg necrosis or myonephropathic metabolic syndrome. The purpose of this study was to evaluate endograft antithrombogenicity by indium-111 platelet scintigraphy. Seventeen patients with abdominal aortic aneurysms were treated by endografting. Thirteen patients were treated with conventional open surgery using an artificial graft. The endograft was constructed from a self-expanding Z-shaped stent and woven polyester fabric. Autologous platelets labeled with indium-111 were injected at 2 weeks postoperatively. At 24 hours and 72 hours postinjection, the ratio of scintillation count of the endograft or graft to that of the native artery was calculated to assess platelet deposition. The normalization ratio was calculated as follows: (scintillation count per pixel of endograft or graft/circumference)/(scintillation count per pixel of the native femoral artery). Platelet factor 4 and beta-thromboglobulin were measured to evaluate the systemic platelets activity at 2 weeks postoperatively. There was no significant difference in platelet counts or labeling efficiency between the groups. The ratio was significantly higher in the endografting group than in the open surgery group at 72 hours postinjection (2.5-0.7 vs 3.9-1.1, P<.001). There was no significant difference in platelet factor 4 and beta-thromboglobulin between the groups. Although there was no difference in systemic platelet activity, endografting was associated with lower antithrombogenicity. It remains unclear whether lower antithrombogenicity causes thromboembolism as a complication of the procedure. The authors recommend the administration of antiplatelet drugs to prevent endograft obstruction in patients with very narrow iliac arteries.
机译：经常有血栓栓塞阻塞移植内肢的报道，并可能导致致命的并发症，例如腿部坏死或肌病性代谢综合征。这项研究的目的是通过111铟血小板闪烁显像技术评估移植物的抗血栓形成性。腹主动脉瘤17例接受了内移植治疗。 13例患者接受了传统的开放式手术，并使用了人工移植物。内移植物由自膨胀Z形支架和机织聚酯纤维制成。术后2周注射标有铟111的自体血小板。在注射后24小时和72小时，计算内移植物或移植物与自然动脉的闪烁计数之比，以评估血小板沉积。归一化比率的计算如下：（内移植物或移植物/周长的每个像素的闪烁数/）天然股动脉的每个像素的闪烁数。术后2周测量血小板因子4和β-血球蛋白以评估全身性血小板活性。两组之间的血小板计数或标记效率无显着差异。内注组在注射后72小时的比例显着高于开放手术组（2.5-0.7 vs 3.9-1.1，P <.001）。两组之间的血小板因子4和β-血球蛋白无显着差异。尽管全身血小板活性没有差异，但是内移植与较低的抗血栓形成性有关。尚不清楚较低的抗血栓形成性是否会引起血栓栓塞，这是手术的并发症。作者建议使用抗血小板药物来预防very动脉非常狭窄的患者的内移植物阻塞。

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