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首页> 外文期刊>Veterinary Dermatology >A systematic review of the evidence of reduced allergenicity and clinical benefit of food hydrolysates in dogs with cutaneous adverse food reactions
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A systematic review of the evidence of reduced allergenicity and clinical benefit of food hydrolysates in dogs with cutaneous adverse food reactions

机译：对皮肤不良食物反应犬的食物水解物降低变应原性和临床益处的证据的系统综述

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Several hydrolysate-based diets have been commercialized for helping diagnose or treat dogs with cutaneous adverse food reactions (CAFR). This systematic review was performed to examine the evidence in favour of reduced immunological and clinical allergenicity of hydrolysates in dogs with CAFR. Citation databases, meeting abstracts and article bibliographies were scanned for relevant citations, and companies were contacted to provide unpublished reports. Eleven studies relevant to this study were identified. Some evidence of reduced serum IgE binding to a soy hydrolysate (1 study) and decreased intradermal test reactivity to hydrolysed proteins (three studies) was found. In four reports, the feeding of dogs suspected of having CAFR with hydrolysate-based diets reduced or eliminated clinical signs in a variable proportion of subjects. The percentage of dogs with CAFR that still reacted to these hydrolysate-based diets could not be assessed, however. Importantly, up to 50% of dogs with CAFR enrolled in three controlled studies exhibited increases in clinical signs after ingesting partial hydrolysates derived from foods to which they were hypersensitive. In conclusion, the limited number of studies undertaken point to reduced - but not eliminated - immunological and clinical allergenicity of hydrolysate-based commercial diets. A variable proportion of dogs with CAFR will exhibit a worsening of clinical signs when fed partial hydrolysates. Clinicians must weigh the clinical benefit of these diets versus their high cost and low risk of reduced appetence or gastrointestinal sign development. At this time, hydrolysate-containing diets are probably best used in dogs suspected not to be hypersensitive to their individual components.
机译：几种基于水解物的饮食已经商业化，以帮助诊断或治疗患有皮肤不良食物反应（CAFR）的狗。进行了这项系统的综述，以检查支持CAFR的犬体内水解产物的免疫学和临床变应原性降低的证据。扫描了引文数据库，会议摘要和文章书目以获取相关引文，并与公司联系以提供未发表的报告。确定了与该研究相关的十一项研究。发现了降低血清IgE与大豆水解物结合的一些证据（1个研究）和降低了皮内测试对水解蛋白的反应性（3个研究）。在四份报告中，以可变比例的受试者喂食怀疑患有CAFR的狗以水解物为基础的饮食可减少或消除其临床体征。但是，尚无法评估仍对这些基于水解产物的饮食起反应的具有CAFR的狗所占的百分比。重要的是，参加了三项对照研究的CAFR犬中，多达50％的犬在摄取了对它们过敏的食品中的部分水解产物后，其临床症状有所增加。总而言之，所进行的有限数量的研究表明，基于水解产物的商业饮食的免疫学和临床变应原性降低了，但并未消除。喂食部分水解物时，不同比例的CAFR犬表现出临床症状恶化。临床医生必须权衡这些饮食的临床益处与它们的高成本和食欲不振或胃肠道症状发展的低风险之间的关系。目前，含水解物的饮食可能最好用于怀疑对自己的个体成分不敏感的狗。

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