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首页> 外文期刊>Veterinary Dermatology >Persistent, widespread papilloma formation on the penis of a horse: a novel presentation of equine papillomavirus type 2 infection.
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Persistent, widespread papilloma formation on the penis of a horse: a novel presentation of equine papillomavirus type 2 infection.

机译：一匹马的阴茎上持续的，广泛的乳头状瘤形成：马2型乳头瘤病毒感染的新颖表现。

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摘要

A 9-year-old gelding presented with approximately 100 papillomas that covered about 75% of the distal penis. Biopsy was performed, and histology showed evidence of viral cytopathic change and koilocytosis. Polymerase chain reaction using DNA extracted from biopsied tissue amplified equine papillomavirus type 2 (EcPV-2) DNA sequences. Sixteen months later, the horse was re-examined and the appearance of the papillomas was unchanged. Equine papillomavirus type 2 DNA sequences were again amplified from both biopsied tissue and swabs of the penis. Papillomavirus was localized to the lesions by immunohistochemistry and in situ hybridization. An examination 2 years after the initial presentation revealed no detectable change in the appearance of the penis. The large number of papillomas and their failure to regress over an extended period support a clinical classification of papillomatosis. To the authors' knowledge, this is the first report of papillomatosis of the equine penis. This novel clinical manifestation suggests that persistent EcPV-2 infection is possible in horses. As there is evidence that EcPV-2 may promote development of equine penile squamous cell carcinoma, understanding the natural history of EcPV-2 infections may be important in preventing equine penile neoplasia.
机译：一个9岁的胶凝表现为大约100个乳头状瘤，覆盖了大约75％的远端阴茎。进行活检，并且组织学显示病毒细胞病变和胆红细胞增多的证据。使用从活检组织中提取的DNA进行的聚合酶链反应扩增了2型马乳头瘤病毒（EcPV-2）DNA序列。 16个月后，对马进行了重新检查，乳头状瘤的外观未变。再次从活检组织和阴茎拭子中扩增出马马乳头瘤病毒2型DNA序列。乳头瘤病毒通过免疫组织化学和原位杂交定位在病变处。最初出现2年后的检查发现阴茎外观没有可检测到的变化。大量的乳头状瘤及其在较长时期内不能退化支持了乳头状瘤病的临床分类。据作者所知，这是马阴茎乳头状瘤病的首次报道。这种新颖的临床表现表明，在马中可能会持续感染EcPV-2。由于有证据表明EcPV-2可能促进马阴茎鳞状细胞癌的发展，因此了解EcPV-2感染的自然史可能对预防马阴茎瘤形成很重要。

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