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首页> 外文期刊>Veterinary Dermatology >In vitro susceptibility testing of meticillin-resistant and meticillin-susceptible staphylococci to mupirocin and novobiocin.
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In vitro susceptibility testing of meticillin-resistant and meticillin-susceptible staphylococci to mupirocin and novobiocin.

机译：耐甲氧西林和耐甲氧西林的葡萄球菌对莫匹罗星和新霉素的体外药敏试验。

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摘要

Antimicrobials effective against meticillin-resistant staphylococci are limited. Mupirocin is a topical antimicrobial used to treat bacterial skin infections. Novobiocin is an oral antimicrobial approved for treatment of staphylococcal upper respiratory infections in dogs. This study reports the in vitro activity of mupirocin and novobiocin on meticillin-susceptible (MSS) and resistant staphylococci (MRS) from healthy dogs and dogs with superficial pyoderma. Staphylococci were isolated from skin swabs at four sites on healthy dogs and from lesions on dogs with superficial pyoderma. Staphylococci were identified by morphology and by catalase and coagulase testing. Speciation and susceptibility testing were performed by the Dade Microscan (W. Sacramento, CA, USA). Meticillin resistance was confirmed by an oxacillin screen plate. Novobiocin and mupirocin susceptibilities were tested by disc diffusion. Staphylococci were cultured from 61 healthy dogs (17 MRS and 44 MSS) and 30 dogs with pyoderma (15 MRS and 15 MSS), with higher proportions of MRS isolates in dogs with pyoderma (P=0.038; chi 2 test). For mupirocin, 79.5% (35 of 44) MSS and 82.3% (14 of 17) MRS isolates from healthy dogs, and 100% (15 of 15) MSS and 86.6% (13 of 15) MRS isolates from dogs with pyoderma were susceptible (MSS, P=0.094; MRS, P=1.0; Fisher's exact test). For novobiocin, 95.4% (42 of 44) MSS and 52.9% (nine of 17) MRS isolates from healthy dogs and 93.3% (14 of 15) MSS and 80% (12 of 15) MRS isolates from dogs with pyoderma were susceptible (MSS, P=1.0; MRS, P=0.148; Fisher's exact test).
机译：对耐甲氧西林的葡萄球菌有效的抗菌剂有限。莫匹罗星是一种用于治疗细菌性皮肤感染的局部抗菌剂。 Novobiocin是一种经批准的口服抗菌剂，可用于治疗犬的葡萄球菌上呼吸道感染。这项研究报告了莫匹罗星和新霉素对健康狗和浅表脓皮病犬的甲氧西林敏感性（MSS）和耐药葡萄球菌（MRS）的体外活性。从健康犬的四个部位的拭子和浅表脓皮病犬的病变中分离出葡萄球菌。通过形态学，过氧化氢酶和凝固酶测试鉴定葡萄球菌。形态和敏感性测试由Dade Microscan（美国加利福尼亚州萨克拉门托市）进行。通过奥沙西林筛板证实耐甲氧西林。通过椎间盘扩散测试新霉素和莫匹罗星的药敏性。从61只健康犬（17 MRS和44 MSS）和30只脓皮病犬（15 MRS和15 MSS）中培养葡萄球菌，在脓皮病犬中MRS分离株比例更高（ P = 0.038; chi 2 测试）。对于莫匹罗星，来自脓毒症狗的79.5％（44中的35）MSS分离株和82.3％（17中的14）MRS分离株和100％（15中的15）MSS和86.6％（15中的13）MRS分离株易感（MSS， P = 0.094; MRS， P = 1.0; Fisher精确检验）。对于新霉素，来自健康狗的95.4％（44中的42）MSS和52.9％（17中的9）MRS分离株和脓毒症犬的93.3％（15 of 14）MSS和80％（15 of 12）的MRS分离株易感（ MSS， P = 1.0; MRS， P = 0.148; Fisher精确检验）。

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