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首页> 外文期刊>Veterinary Dermatology >High allergen-specific serum immunoglobulin E levels in nonatopic West Highland white terriers.
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High allergen-specific serum immunoglobulin E levels in nonatopic West Highland white terriers.

机译：在非特应性西高地白梗中高变应原特异性血清免疫球蛋白E水平。

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Human and canine atopic dermatitis (AD) share an association with IgE specific to environmental allergens, but few studies have evaluated serum allergen-specific IgE in nonatopic dogs. This study compared serum allergen-specific IgE levels in 30 atopic and 18 nonatopic West Highland white terriers. Atopic dermatitis was confirmed using standard criteria. Nonatopic dogs were over 5 years of age and had no clinical signs or history of AD. Serum allergen-specific IgE levels were measured with AllerceptReg. IgE ELISAs using a 48-allergen Australian panel. Positive reactions were defined as >=150 ELISA absorbance units. Intradermal tests were performed in 16 atopic dogs, either at the time of or at various times prior to serum collection. In atopic dogs, the most common positive ELISA and intradermal test results were to Dermatophagoides farinae (11 of 30 dogs), but there were no statistically significant correlations between results from the two methods for any allergen. In nonatopic dogs, multiple high-positive ELISA reactions were reported to 45 of 48 allergens, most commonly D. farinae and Tyrophagus putrescentiae (17 of 18 dogs each). Positive ELISA results in nonatopic dogs were statistically significantly higher than those in atopic dogs for 44 of 48 allergens, including two allergens (D. farinae and Dermatophagoides pteronyssinus) commonly regarded as significant in canine AD. In conclusion, positive allergen-specific IgE ELISAs were not specific for canine AD, and high allergen-specific IgE levels were seen in nonatopic dogs. The clinical significance of this and whether it characterizes a protective phenotype is unclear.
机译：人和犬特应性皮炎（AD）与环境变应原特异的IgE有关联，但是很少有研究评估非特应性犬的血清变应原特异IgE。这项研究比较了30种特应性和18种非特应性西高地白梗的血清过敏原特异性IgE水平。使用标准标准确认特应性皮炎。非特应性犬超过5岁，没有临床体征或AD史。用AllerceptReg测量血清过敏原特异性IgE水平。使用48种过敏原的澳大利亚专家组进行IgE ELISA。阳性反应定义为> = 150 ELISA吸光度单位。在16只特应性犬中进行血清内或皮下采集之前或之后的不同时间进行皮内测试。在特应性犬中，最常见的ELISA阳性结果和皮内试验结果是 Dermatophagoides farinae （30只狗中的11只），但是两种方法对任何过敏原的结果之间均无统计学意义的相关性。在非特应性犬中，据报道48种过敏原中有45种发生了多个高阳性ELISA反应，最常见的是D。 farinae 和 Tyrophagus putrescentiae （每18只狗中有17只）。在48种过敏原中，非特应性狗的ELISA阳性结果在统计学上显着高于特应性狗，其中包括通常被认为是显着的两种过敏原（ farinae 和 Dermatophagoides pteronyssinus ）。在犬广告中。总之，过敏原特异性IgE ELISA阳性对犬AD并不特异，并且在非特应性犬中发现了较高的过敏原特异性IgE水平。目前尚不清楚其是否具有保护性表型的临床意义。

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