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首页> 外文期刊>Veterinary Dermatology >Genotyping of Malassezia pachydermatis isolates from canine healthy skin and atopic dermatitis by internal spacer 1 (IGS1) region analysis.
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Genotyping of Malassezia pachydermatis isolates from canine healthy skin and atopic dermatitis by internal spacer 1 (IGS1) region analysis.

机译：通过内部间隔区1（IGS1）区域分析，从健康的皮肤和特应性皮炎中分离出帕拉氏疟原虫分离株的基因型。

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摘要

Isolates of Malassezia pachydermatis from healthy dog skin and from dogs with atopic dermatitis were molecularly characterized using internal spacer 1 (IGS1) region analyses, and their phospholipase A2 activity and pH growth profiles were then characterized in vitro. The percentage of isolates from healthy dogs that had the following IGS1 subtypes (isotype, %) were as follows: 1A, 6%; 1B, 27%; 1C, 11%; 2A, 6%; 2B, 6%; 3A, 11%; 3C, 3%; and 3D, 24%. In contrast, 9% of isolates from dogs with atopic dermatitis were isotype IB and 91% were isotype 3D, indicating that isolates of subtype 3D were the most prevalent in dogs with atopic dermatitis. Production of phospholipase A2 was statistically higher in isolates of subtype 3D than in the other subtypes. The subtype 3D isolates showed enhanced growth on alkaline medium compared with non-3D subtype isolates. The main clinical sign of canine Malassezia dermatitis is waxy exudates on the skin, which predispose the patient to development of a yeast overgrowth of the subtype 3D. Increased phospholipase A2 production may be involved in the inflammatory process associated with Malassezia dermatitis.
机译：使用内部间隔区1（IGS1）区域分析从健康犬皮肤和特应性皮炎犬中分离出帕拉氏疟原虫的分子，然后表征其磷脂酶A2活性和pH值增长曲线。体外。具有以下IGS1亚型（同种型，％）的健康犬分离株的百分比如下：1A，6％; 1B，27％; 1C，11％; 2A，6％; 2B，6％; 3A，11％; 3C，3％;和3D，占24％。相比之下，特应性皮炎犬的分离株中9％是IB型，而3D型则是91％，这表明3D亚型分离株在特应性皮炎犬中最普遍。 3D亚型分离株中磷脂酶A2的产生在统计学上高于其他亚型。与非3D亚型分离株相比，亚型3D分离株在碱性培养基上显示出增强的生长。犬马拉色氏皮炎的主要临床体征是皮肤上的蜡状渗出液，这使患者易于发展为3D亚型的酵母菌。磷脂酶A2产生增加可能与 Malassezia 皮炎相关的炎症过程有关。

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