• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Veterinary Ophthalmology >Superficial corneal squamous cell carcinoma occurring in dogs with chronic keratitis
【24h】

Superficial corneal squamous cell carcinoma occurring in dogs with chronic keratitis

机译：慢性角膜炎狗中发生浅表角膜鳞状细胞癌

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

ObjectiveCanine corneal squamous cell carcinoma (SCC) is a rare tumor, with only eight cases previously published in the veterinary literature. The Comparative Ocular Pathology Lab of Wisconsin (COPLOW) has diagnosed 26 spontaneously occurring cases, 23 in the past 4 years. This retrospective study describes age and breed prevalence, concurrent therapy, biologic behavior, tumor size and character, and 6-month survival rates after diagnosis.ResultsA search of the COPLOW database identified 26 corneal SCC cases diagnosed from 1978 to 2008. There is a strong breed predilection (77%) in brachycephalic breeds, particularly those prone to keratoconjunctivitis sicca. The mean age was 9.6 years (range 6-14.5 years). Follow-up information > 6 months was available for 15 of 26 cases. Recurrence occurred in the same eye in nine cases, seven of which were incompletely excised at the time of first keratectomy. No cases were known to have tumor growth in the contralateral eye and no cases of distant metastases are known. Where drug history is known, 16 of 21 dogs had a history of treatment with topical immunosuppressive therapy (cyclosporine or tacrolimus) at the time of diagnosis.ConclusionChronic inflammatory conditions of the cornea and topical immunosuppressive therapy may be risk factors for developing primary corneal SCC in dogs. SCC should be considered in any differential diagnosis of corneal proliferative lesions. Superficial keratectomy with complete excision is recommended, and the metastatic potential appears to be low.
机译：目的犬角膜鳞状细胞癌（SCC）是一种罕见的肿瘤，以前仅在兽医文献中发表过八例。威斯康星比较眼病理学实验室（COPLOW）已诊断出26例自发性病例，过去4年中诊断出23例。这项回顾性研究描述了年龄和品种的患病率，同时治疗，生物学行为，肿瘤的大小和特征以及诊断后6个月的存活率。结果在COPLOW数据库中搜索了1978年至2008年诊断出的26例角膜SCC病例。头颅型，特别是那些容易发生干燥性角结膜炎的物种中，这种类型的患病率最高（77％）。平均年龄为9.6岁（范围为6-14.5岁）。 26例病例中有15例的随访信息> 6个月。在同一只眼中有9例复发，其中7例在第一次角膜切除术时未完全切除。没有发现对侧眼有肿瘤生长的病例，也没有远处转移的病例。在已知药物史的情况下，每21只狗中有16只在诊断时有局部免疫抑制治疗（环孢素或他克莫司）的治疗史。小狗。在任何角膜增生性病变的鉴别诊断中均应考虑SCC。建议进行完全切除的浅表角膜切除术，并且转移潜力似乎较低。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号