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首页> 外文期刊>Veterinary Ophthalmology >Comparison of the effect of hypertonic hydroxyethyl starch and mannitol on the intraocular pressure in healthy normotensive dogs and the effect of hypertonic hydroxyethyl starch on the intraocular pressure in dogs with primary glaucoma
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Comparison of the effect of hypertonic hydroxyethyl starch and mannitol on the intraocular pressure in healthy normotensive dogs and the effect of hypertonic hydroxyethyl starch on the intraocular pressure in dogs with primary glaucoma

机译：高渗羟乙基淀粉和甘露醇对健康血压正常犬眼压的影响及高渗羟乙基淀粉对原发性青光眼犬眼压的影响

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PURPOSE: The purpose of this study was to determine if intravenous hypertonic hydroxyethyl starch (7.5%/6%) (HES) could decrease the intraocular pressure (IOP) in healthy normotensive dogs, and compare its effect with that of mannitol (20%) (experimental study). In addition, the potential IOP-lowering effect of hypertonic HES was evaluated in six dogs with primary glaucoma (clinical study). MATERIAL AND METHODS: Experimental study: eight male ophthalmoscopically and clinically healthy Beagles were included in this study. The IOP of each dog was measured by applanation tonometry in both eyes to obtain control values at 10:00, 10:15, 10:30, 10:45, 11:00 a.m., and then every hour until 6:00 p.m. prior to the first treatment (control period). Each dog received, with at least 2-week intervals and in a random order, an intravenous (IV) infusion of 4 mL/kg hypertonic HES (1.2 g/kg NaCl; 0.96 g/kg HES) and 4 mL/kg mannitol 20% (1 g/kg) over a period of 15 min starting at 10:00 a.m. IOP was measured oculus uterque (OU) at the same time intervals as in the control study. The differences in IOP between the treatment groups and the baseline IOP (before the start of infusion), between oculus sinister (OS) and oculus dexter (OD) and between the same time points of all groups were determined with a Student's t-test for paired samples (P = 0.05). Clinical study: six dogs with primary glaucoma (representing seven eyes) received an IV infusion of 4 mL/kg hypertonic HES over a period of 15 min. IOP was measured before and 15 and 30 min after starting the infusion. RESULTS: Experimental study: no significant difference between IOP of both eyes was found. A significant decrease in IOP from baseline value was recorded at 15, 30, 45, and 60 min after the start of mannitol infusion (mean amplitude in IOP decrease 3.21 mmHg; P < 0.05) and at 15 and 30 min in dogs treated with HES (mean amplitude in IOP decrease 2.43 mmHg; P < 0.05). At 120 and 180 min there was a significantly higher IOP (P < 0.05) in HES treatment group compared to the values of the control group. Clinical study: in 5/7 eyes diagnosed with primary glaucoma a maximum decrease in IOP of an average of 24% from the baseline value (IOP before start of the infusion) was observed (range of decrease 2-21 mmHg). In three of these five cases the maximum decrease was reached at 15 min and in two cases at 30 min. In one case an increase in IOP of 35% (+ 18 mmHg) was seen after 15 min and 26% (+ 13 mmHg) after 30 min. Case 4 showed an increase in IOP of 5% (+ 3 mmHg) after 15 min and a decrease of 6% (- 4 mmHg) after 30 min. CONCLUSIONS: Intravenous hypertonic HES is comparable to intravenous mannitol 20% in lowering the intraocular pressure in healthy normotensive dogs. But this effect lasted half an hour longer after mannitol. In 6/7 eyes with primary glaucoma, hypertonic HES decreased IOP.
机译：目的：本研究的目的是确定静脉内高渗羟乙基淀粉（7.5％/ 6％）（HES）是否可以降低健康血压正常犬的眼内压（IOP），并将其与甘露醇（20％）的作用进行比较（实验研究）。另外，在六只患有原发性青光眼的狗中评估了高渗性HES降低IOP的潜在作用（临床研究）。材料与方法：实验研究：八只雄性在眼底镜下和临床上健康的比格犬都包括在本研究中。通过压平眼压法在两只眼睛上测量每只狗的IOP，以在上午10：00、10：15、10：30、10：45、11：00，然后每小时直到下午6:00取得对照值。在第一次治疗之前（控制期）。每只狗以至少2周的间隔并以随机顺序接受静脉（IV）输注4 mL / kg高渗HES（1.2 g / kg NaCl; 0.96 g / kg HES）和4 mL / kg甘露醇20在上午10:00开始的15分钟内，以与对照组研究相同的时间间隔测量子宫内膜异位症（OU）的IOP（％（1 g / kg））。用Student's t检验确定治疗组与基线IOP（开始输注之前），oculus sinister（OS）和oculus dexter（OD）之间以及所有组的相同时间点之间的IOP差异。配对样本（P = 0.05）。临床研究：六只患有原发性青光眼的狗（代表七只眼睛）在15分钟内接受了4 mL / kg高渗HES的静脉输注。在开始输注之前以及输注后15和30分钟测量IOP。结果：实验研究：两只眼睛的IOP之间没有发现显着差异。甘露醇开始输注后第15、30、45和60分钟，IOP较基线值显着下降（IOP平均幅度下降3.21 mmHg; P <0.05），HES治疗的狗在第15和30分钟（IOP的平均幅度降低了2.43 mmHg; P <0.05）。与对照组相比，HES治疗组在120和180分钟时的IOP显着更高（P <0.05）。临床研究：在诊断为原发性青光眼的5/7眼中，观察到的IOP相对于基线值（输注开始前的IOP）平均平均降低了24％（降低范围为2-21 mmHg）。在这五个案例中的三个案例中，在15分钟时达到最大降低，而在两个案例中，则在30分钟时达到最大降低。在一种情况下，观察到15分钟后IOP升高35％（+ 18 mmHg），30分钟后IOP升高26％（+ 13 mmHg）。案例4显示15分钟后IOP增加5％（+ 3 mmHg），而30分钟后IOP减少6％（-4 mmHg）。结论：在健康的血压正常的狗中，静脉高渗HES在降低眼内压方面可与静脉甘露醇20％相媲美。但是这种作用在甘露醇之后持续了半小时。在患有原发性青光眼的6/7眼中，高渗性HES降低了IOP。

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