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Is single-dose, full-course therapy here to stay?

机译：单剂量，全疗程是否可以保留？

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摘要

A new term has crept into the large animal vet's vocabulary over the last year or so: single-dose, full-course therapy. Its emergence is largely due to the success of a new cattle and swine treatment that was launched across Europe last year. But does this new concept deserve a description all of its own, or is it more hype than help? The treatment in question is Draxxin: an antibacterial treat ment based on tulathromycin, the first of a new class of drugs called triamilides. The thing that sets it apart from other treatments is not its mode of action, or route of administration, but its duration of action. Just one injection produces lung tissue concentrations of active drug which remain above the MIC values of common respiratory pathogens for at least 9 days in catde and 5 days in swine - far longer than any comparable treatment. As a result, it can not only achieve an effective bacteriological and clinical cure, but also extend antibacterial cover into the post-cure recovery period. It is during this critical time, when the animal's natural defence mechanisms are still recovering, that the risk of relapse or re-infection is highest.
机译：过去一年左右的时间里，大型动物兽医的词汇量增加了一个新名词：单剂量，全过程疗法。它的出现很大程度上归功于去年在欧洲推出的新型牛和猪治疗方法的成功。但是，这个新概念是否值得对其进行完整描述，还是比帮助更夸大其词？有争议的治疗方法是德拉克辛（Draxxin）：一种基于图拉霉素的抗菌治疗方法，它是一种名为三酰胺的新型药物中的第一种。使它与其他治疗区分开来的不是它的作用方式或给药途径，而是它的作用持续时间。仅一次注射即可产生活性药物的肺组织浓度，在猫中至少9天，在猪中至少5天保持高于常见呼吸道病原体的MIC值-远远长于任何可比的治疗方法。结果，它不仅可以实现有效的细菌学和临床治愈，而且可以将抗菌覆盖范围扩展到治愈后的恢复期。在关键时刻，当动物的自然防御机制仍在恢复时，复发或再次感染的风险最高。

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