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首页> 外文期刊>Urology >Single-dose fluoroquinolone therapy of acute uncomplicated urinary tract infection in women: results from a randomized, double-blind, multicenter trial comparing single-dose to 3-day fluoroquinolone regimens.
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Single-dose fluoroquinolone therapy of acute uncomplicated urinary tract infection in women: results from a randomized, double-blind, multicenter trial comparing single-dose to 3-day fluoroquinolone regimens.

机译：女性急性单纯性尿路感染的单剂量氟喹诺酮疗法：一项比较单剂量和3天氟喹诺酮方案的随机，双盲，多中心试验的结果。

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OBJECTIVES: To compare the efficacy and safety of single-dose and 3-day fluoroquinolone treatment of uncomplicated urinary tract infection (UTI). METHODS: Adult women with acute uncomplicated UTI were randomized to receive either a single dose of gatifloxacin (400 mg), 3 days of gatifloxacin (200 mg daily), or 3 days of ciprofloxacin (100 mg twice daily). Patients were assessed at four points during the study: before treatment (within 48 hours before the initiation of the study medication), at the end of treatment (by telephone contact on day 3), and twice after treatment completion (5 to 9 days after treatment [test-of-cure visit] and 29 to 42 days after treatment [only patients with a bacteriologic response of eradication at the test-of-cure visit]). RESULTS: The bacterial eradication rate for the single-dose gatifloxacin, 3-day gatifloxacin, and 3-day ciprofloxacin groups was 90%, 95%, and 89%, respectively; the clinical efficacy rate was 93%, 95%, and 93%, respectively, for microbiologically assessable patients at the test-of-cure visit. Eradication of the most common uropathogens, including Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis, was achieved with gatifloxacin and ciprofloxacin. Single-dose gatifloxacin was equivalent to 3-day ciprofloxacin in both microbiologic and clinical efficacy. CONCLUSIONS: Single-dose and 3-day gatifloxacin were microbiologically and clinically equivalent to 3-day ciprofloxacin for the treatment of acute UTI among women. Single-dose gatifloxacin may offer advantages over 3-day fluoroquinolone therapy for uncomplicated UTI by decreasing secondary use of medical resources and improving patient compliance.
机译：目的：比较单剂量和三天氟喹诺酮治疗单纯性尿路感染（UTI）的疗效和安全性。方法：将急性单纯性尿路感染的成年女性随机分为单剂量加替沙星（400 mg），加替沙星3天（每天200 mg）或环丙沙星3天（100 mg每天两次）。在研究过程中的四个点对患者进行了评估：治疗之前（开始研究药物治疗前48小时内），治疗结束时（第3天通过电话联系）以及治疗完成后两次（治疗后5至9天）治疗[治疗后就诊]和治疗后29至42天[仅在治疗后就诊具有根除细菌反应的患者]。结果：单剂量加替沙星，3天加替沙星和3天环丙沙星组的细菌清除率分别为90％，95％和89％。在就诊测试中，通过微生物学评估的患者的临床疗效分别为93％，95％和93％。使用加替沙星和环丙沙星可以消除最常见的尿路致病菌，包括大肠杆菌，肺炎克雷伯菌和奇异变形杆菌。在微生物学和临床疗效上，单剂量加替沙星相当于3天环丙沙星。结论：单药和3天加替沙星在微生物和临床上等效于3天环丙沙星治疗女性急性尿路感染。单剂量加替沙星可通过减少医疗资源的二次使用并改善患者依从性，提供优于3天氟喹诺酮类药物治疗单纯性UTI的优势。

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