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首页> 外文期刊>Viral immunology >Human Cytomegalovirus-Specific CD4(+) T-Cell Clones Recognize Cross-Reactive Peptides From the Immediate Early 1 Protein.
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Human Cytomegalovirus-Specific CD4(+) T-Cell Clones Recognize Cross-Reactive Peptides From the Immediate Early 1 Protein.

机译：人类巨细胞病毒特异的CD4（+）T细胞克隆可识别来自早期早期1蛋白的交叉反应肽。

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摘要

Human cytomegalovirus (HCMV) is a beta-herpes virus that persists in a latent state in immunocompetent individuals. Both CD4(+) and CD8(+) T lymphocytes have been reported to be present at a high frequency in HCMV-seropositive individuals and are involved in the control of infection. How such frequencies are maintained is not completely understood. We have observed that the canonical HLADR8 epitope of the immediate early 1 protein (IE1) contained in the IE1 (156-175) sequence shares homologies with an IE1 sequence contained in part in the previously reported HLA-DR3 epitope, IE1 (91-110). We thus wondered whether such homology in a single protein would translate into recognition of the IE1 homolog sequence by HLA-DR8-restricted CD4(+) cells in addition to the canonical epitope. We found that established HLA-DR8-restricted T cell clones are also able to cross-recognize the IE1 (91-110) peptide, as well as a shorter 14-mer, IE1 (91-104). Moreover, the homolog peptide IE1 (91-110) was able to generate, from a seropositive blood donor, new IE1-specific, HLA-DR8-restricted CD4(+) T cell clones that were also cross-reactive. Those findings may provide clues to the formation and regulation of the T-cell repertoire and memory.
机译：人类巨细胞病毒（HCMV）是一种β疱疹病毒，在具有免疫能力的个体中以潜伏状态持续存在。据报道，在HCMV血清反应阳性的个体中CD4（+）和CD8（+）T淋巴细胞均以高频率存在，并参与感染的控制。如何维持这种频率尚不完全清楚。我们已经观察到IE1（156-175）序列中包含的立即早期1蛋白（IE1）的规范HLADR8表位与先前报道的HLA-DR3表位IE1（91-110）中部分包含的IE1序列具有同源性）。因此，我们想知道单个蛋白质中的这种同源性是否会转化为HLA-DR8限制性CD4（+）细胞除标准表位外对IE1同源序列的识别。我们发现，已建立的HLA-DR8限制性T细胞克隆也能够交叉识别IE1（91-110）肽，以及较短的14-mer IE1（91-104）。此外，同源肽IE1（91-110）能够从血清阳性的血液供体中产生新的IE1特异性，HLA-DR8限制性的CD4（+）T细胞克隆，它们也具有交叉反应性。这些发现可能为T细胞库和记忆的形成和调控提供线索。

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