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首页> 外文期刊>Virchows Archiv: an international journal of pathology >Innervation of human adrenal gland and adrenal cortical lesions.
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Innervation of human adrenal gland and adrenal cortical lesions.

机译：人肾上腺和肾上腺皮质病变的神经。

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摘要

The innervation of the human adrenal gland and of cortical lesions was studied in sections of cortical tissue (n=10), hyperplastic cortical tissue (n=3), and tissue from cortical adenomas (n=5) and carcinomas (n=6). The presence and distribution of nerve structures containing neuronal markers indicating sympathetic and parasympathetic innervation were studied by immunohistochemistry and the co-existence and co-localization patterns of the different markers by immunofluorescence. The cortex and hyperplastic cortical tissue had a moderate to rich supply of nerve structures containing the typical neuronal markers: protein gene product 9.5 (PGP 9.5), neuron-specific enolase (NSE), small vesicle synaptic protein type 2 (SV2), and nerves showing immunoreactivity to the adrenergic marker tyrosine hydroxylase (TH). All these immunoreactive nerves were located predominantly adjacent to blood vessels, but also among parenchymal cells. The cortex showed numerous nerve structures containing the neuropeptide substance P (SP), neuropeptide Y (NPY) and vasoactive intestinal protein (VIP), but few nerves containing these peptides were seen in hyperplastic cortical tissue. Typical markers were occasionally observed in cortical adenomas but were not found in carcinomas, except in a few cases where PGP 9.5 and NSE were present, but only adjacent to necrotic areas. Nerves containing NPY and VIP occurred in varying numbers in both adenomas and carcinomas. NPY- and VIP-immunoreactive nerve structures were seen mostly alongside blood vessels. There were several types of co-existence. For instance, NSE/VIP-, TH/VIP- and TH/NPY-immunoreactive nerve structures were often seen in the same trunk, but were only partly co-localized.
机译：在皮质组织（n = 10），增生性皮质组织（n = 3）以及皮质腺瘤（n = 5）和癌组织（n = 6）的切片中研究了人类肾上腺和皮质病变的神经。通过免疫组织化学研究了包含指示交感神经和副交感神经支配的神经元标志物的神经结构的存在和分布，并通过免疫荧光研究了不同标志物的共存和共定位模式。皮质和增生性皮质组织具有中度至丰富的神经结构供应，其中包含典型的神经元标记：蛋白基因产物9.5（PGP 9.5），神经元特异性烯醇化酶（NSE），小囊泡突触蛋白2型（SV2）和神经对肾上腺素标记酪氨酸羟化酶（TH）具有免疫反应性。所有这些免疫反应性神经主要位于血管附近，但也位于实质细胞之间。皮质显示出许多神经结构，其中包含神经肽物质P（SP），神经肽Y（NPY）和血管活性肠蛋白（VIP），但在增生性皮质组织中几乎看不到含有这些肽的神经。除了在少数存在PGP 9.5和NSE的病例中，仅在坏死区域附近，在皮质腺瘤中偶尔观察到典型的标志物，但在癌中未发现典型的标志物。包含NPY和VIP的神经在腺瘤和癌中均以不同数量出现。 NPY和VIP免疫反应性神经结构大多位于血管旁。共存有几种类型。例如，NSE / VIP-，TH / VIP-和TH / NPY免疫反应性神经结构经常出现在同一躯干中，但仅部分共定位。

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