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首页> 外文期刊>Virus Genes >The evolution of two homologues of the core protein VP6 of epizootic haemorrhagic disease virus (EHDV), which correspond to the geographical origin of the virus.
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The evolution of two homologues of the core protein VP6 of epizootic haemorrhagic disease virus (EHDV), which correspond to the geographical origin of the virus.

机译：流行性出血病病毒（EHDV）核心蛋白VP6的两个同源物的进化，与该病毒的地理起源相对应。

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摘要

Epizootic haemorrhagic disease virus is a 10-segmented, double-stranded RNA virus. When these ten segments of dsRNA are run on 1% agarose, eastern (Australia, Japan) and western (North America, Africa, Middle-East) strains of the virus can be separated phenotypically based on the migration of genome segments 7-9. In western strains, segments 7-9 are roughly the same size and co-migrate as a single RNA band. In eastern strains, segment 9 is smaller, so while segments 7 and 8 co-migrate, the segment 9 RNA runs faster than its western homologue. Translation experiments demonstrated that these two segment 9 homologues are both functional and produce proteins (VP6) of different sizes-something that has not been reported in any other orbivirus species to date. Sequence analysis suggests that eastern and western versions of segment 9 (VP6) have likely evolved as a response to adaptive selection in different geographical regions via gene duplication and subsequent mutation. These significant findings are considered unusual given the conserved nature of VP6 and its presumed role as the viral helicase. It is not currently known what the biological relevance of each homologue is to the virus.
机译：流行性出血病病毒是一种10段双链RNA病毒。当在10％的琼脂糖上运行dsRNA的这10个片段时，可以根据基因组片段7-9的迁移在表型上分离病毒的东部（澳大利亚，日本）和西部（北美，非洲，中东）病毒株。在西方菌株中，区段7-9的大小大致相同，并且与单个RNA条带共同迁移。在东部菌株中，区段9较小，因此，当区段7和8共迁移时，区段9 RNA的运行速度比其西方同源物更快。翻译实验表明，这两个9段同源物均具有功能，并产生不同大小的蛋白质（VP6）-迄今为止，尚无其他任何双病毒种报道。序列分析表明，第9节（VP6）的东部和西部版本可能已通过基因复制和随后的突变演变为对不同地理区域的适应性选择的反应。考虑到VP6的保守性质及其作为病毒解旋酶的假定作用，这些重要发现被认为是不寻常的。目前尚不清楚每个同源物与病毒的生物学相关性。

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