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首页> 外文期刊>The International journal of pharmacy practice >Utilization patterns of antiepileptic drugs among adult epileptic patients at a tertiary hospital in Oman
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Utilization patterns of antiepileptic drugs among adult epileptic patients at a tertiary hospital in Oman

机译：阿曼一家三级医院的成年癫痫患者使用抗癫痫药的方式

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Objectives To describe utilization patterns of antiepileptic drugs (AEDs) among adult epileptic patients at a tertiary hospital in Oman. Methods Data were collected retrospectively from January 2006 to December 2009. The study included all adult (>18 years) epileptic patients on AEDs and followed up at a neurology clinic at Sultan Qaboos University Hospital in Oman. All reported therapeutic drug monitoring (TDM) requests for serum AED concentrations were also collected. Institutional ethical approval was sought and obtained. Key findings The study included a total of 372 patients with a mean age of 34 ± 15 years. Monotherapy AEDs accounted for 53% of the prescriptions, whereas polytherapy with two or three AED combinations accounted for 27% and 20% respectively. The most frequently prescribed AED was sodium valproate (27%) followed by carbamazepine (23%). The commonly prescribed AED combinations were sodium valproate with clonazepam (12%) followed by sodium valproate with lamotrigine (12%). Evaluation of 574 TDM requests for three AEDs showed that 57% of carbamazepine, 78% of phenytoin and 54% of valproic acid requests were either above or below the recommended therapeutic threshold. Most of these requests were ordered from the hospital's emergency department for suspected insufficient serum concentrations. Conclusions Antiepileptic drug monotherapy is still the most frequently employed therapeutic strategy in adult patients with epilepsy in keeping with the standard therapeutic guidelines. Sodium valproate is commonly used for different types of seizures reflecting its wide spectrum of anticonvulsant potential. Newer AED utilizations are becoming increasingly popular in our subjects particularly as add-on with other standard AEDs.
机译：目的描述在阿曼一家三级医院的成年癫痫患者中抗癫痫药物（AED）的使用模式。方法回顾性收集2006年1月至2009年12月的数据。该研究包括所有成年（> 18岁）接受AED治疗的癫痫患者，并在阿曼苏丹卡布斯大学医院的神经内科诊所进行了随访。还收集了所有报告的治疗药物监测（TDM）对血清AED浓度的要求。寻求并获得了机构伦理上的认可。主要发现该研究共纳入372名患者，平均年龄为34±15岁。单一疗法的AED占处方的53％，而两种或三种AED组合的多重疗法分别占27％和20％。最常用的AED是丙戊酸钠（27％），然后是卡马西平（23％）。常用的AED组合为丙戊酸钠与氯硝西am（12％），然后丙戊酸钠与拉莫三嗪（12％）。对3种AED的574种TDM要求的评估显示，有57％的卡马西平，78％的苯妥英钠和54％的丙戊酸的要求高于或低于建议的治疗阈值。由于怀疑血清浓度不足，大多数此类请求是从医院急诊科订购的。结论抗癫痫药物单药治疗仍然是成人癫痫患者最常用的治疗策略，符合标准治疗指南。丙戊酸钠通常用于不同类型的癫痫发作，反映出其广泛的抗惊厥潜能。新型AED的使用在我们的学科中正变得越来越流行，尤其是与其他标准AED一起使用时。

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