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首页> 外文期刊>The International journal of pharmacy practice >Effect of information leaflets and counselling on antidepressant adherence: open randomised controlled trial in a psychiatric hospital in Kuwait
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Effect of information leaflets and counselling on antidepressant adherence: open randomised controlled trial in a psychiatric hospital in Kuwait

机译：信息传单和咨询对抗抑郁药依从性的影响：科威特一家精神病医院的开放随机对照试验

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Objective To assess the acceptability and effectiveness of two educational initiatives on patterns of antidepressant medication use in depressed Kuwaiti patients.Setting Patients were interviewed on three occasions at the Psychological Medicine Hospital, Kuwait.Method Two-hundred and seventy-eight patients attending a hospital outpatient clinic in Kuwait and receiving a single antidepressant for mild or moderate depression were randomised into a control and two treatment groups. Medication was dispensed from the pharmacy as normal. However, members of the treatment groups additionally received a patient information leaflet (PIL) written in Arabic with or without counselling from a clinical pharmacist. Medication adherence was monitored 2 months and 5 months later by self-report and tablet counting. Patient knowledge of medication and the acceptability of the educational interventions were assessed after 2 months using questionnaires.Key findings Patients in each of the treatment groups had an improved knowledge of the rationale behind their therapy. Clinic attendance was more likely when patients had received a PIL (odds ratio (OR) 2.1, 95% confidence interval (Cl) 1,3-3.2) or a PIL plus counselling (OR 3.2, Cl 2.1-4.9). Good medication adherence at 2 and 5 months was more common in patients who were given a PIL (OR 3.0, Cl 1.7-5.3) or a PIL plus counselling (OR 5.5, Cl 3.2-9.6). Certain pre-existing patient attitudes to therapy and the occurrence of side-effects were not determinants of adherence. Conclusions Patient responses to each of these educational interventions were very positive. After 5 months, patients receiving a PIL were more likely to be adhering to their medication regimen, particularly when they had also received counselling from a clinical pharmacist.
机译：目的评估科威特抑郁症患者抗抑郁药物使用方式的两种教育举措的可接受性和有效性。方法在科威特心理医学医院对患者进行了三次访谈。方法有278名患者在医院门诊就诊。在科威特的门诊接受单一抗抑郁药治疗的轻度或中度抑郁症患者被随机分为对照组和两个治疗组。照常从药房配药。但是，在有或没有临床药师指导的情况下，治疗组的成员还收到了以阿拉伯语撰写的患者信息单张（PIL）。 2个月和5个月后通过自我报告和药片计数监测药物依从性。 2个月后，通过问卷调查评估患者对药物的了解和教育干预措施的可接受性。主要发现每个治疗组的患者对治疗依据的了解有所提高。当患者接受PIL（优势比（OR）2.1、95％置信区间（Cl）1,3-3.2）或PIL加咨询（OR 3.2，Cl 2.1-4.9）时，就诊的可能性更高。接受PIL（OR 3.0，Cl 1.7-5.3）或PIL加咨询（OR 5.5，Cl 3.2-9.6）的患者在2和5个月时良好的药物依从性更为常见。某些患者先前对治疗的态度以及副作用的发生并非依从性的决定因素。结论患者对上述每种教育干预措施的反应都非常积极。 5个月后，接受PIL的患者更有可能坚持其用药方案，特别是当他们还接受了临床药剂师的咨询时。

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