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首页> 外文期刊>Phytotherapy research: PTR >Protective effects of an herbal formulation of Radix Astragali, Radix Codonopsis and Cortex Lycii on streptozotocin-induced apoptosis in pancreatic beta-cells: An implication for its treatment of diabetes Mellitus
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Protective effects of an herbal formulation of Radix Astragali, Radix Codonopsis and Cortex Lycii on streptozotocin-induced apoptosis in pancreatic beta-cells: An implication for its treatment of diabetes Mellitus

机译：黄芪，党参，枸杞等中草药制剂对链脲佐菌素诱导的胰腺β细胞凋亡的保护作用：对糖尿病的治疗意义

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摘要

Hyperglycemia is one of the main causes of oxidative stress in type 2 diabetes mellitus. During hyperglycemia, the increased level of various reducing sugars in the blood enhances the production of reactive oxygen species (ROS) and triggers tissue damage, especially in pancreatic beta-cells. Streptozotocin (STZ) is a diabetogen that causes diabetes mellitus via ROS-induced apoptosis in beta-cells. In this study, SR10, an herbal formulation consisting of the aqueous extracts of Radix Astragali, Radix Codonopsis and Cortex Lycii was examined for its antidiabetic effects in vitro. SR10 treatment resulted in significant enhancement of survival rate of rat pancreatic beta-cells; which were treated by streptozotocin. SR10 apparently reduced apoptosis of streptozotocin-treated beta-cells by decreasing DNA fragmentation, sub-G(1) peak area and percentage of apoptotic cells. Nitric oxide (NO) production in streptozotocin-treated cells was inhibited by SR10 via the suppression of the expression of inducible nitric oxide synthase (MOS). The implication of SR10 in treating type 2 diabetes mellitus was discussed. Copyright (C) 2007 John Wiley & Sons, Ltd.
机译：高血糖是2型糖尿病中氧化应激的主要原因之一。在高血糖症期间，血液中各种还原糖含量的增加会增加活性氧（ROS）的产生并触发组织损伤，特别是在胰腺β细胞中。链脲佐菌素（STZ）是一种糖尿病源，可通过ROS诱导β细胞凋亡来引起糖尿病。在这项研究中，SR10是一种由黄芪，党参和枸杞的水提取物组成的草药制剂，在体外具有抗糖尿病作用。 SR10处理可显着提高大鼠胰腺β细胞的存活率;用链脲佐菌素治疗。 SR10显然通过减少DNA片段化，sub-G（1）峰面积和凋亡细胞的百分比减少了链脲霉素处理过的β细胞的凋亡。 SR10通过抑制诱导型一氧化氮合酶（MOS）的表达来抑制链脲佐菌素处理的细胞中一氧化氮（NO）的产生。讨论了SR10在治疗2型糖尿病中的意义。版权所有（C）2007 John Wiley＆Sons，Ltd.

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