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首页> 外文期刊>Phytotherapy research: PTR >The Potential of Sub-Saharan African Plants in the Management of Human Immunodeficiency Virus Infections: A Review
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The Potential of Sub-Saharan African Plants in the Management of Human Immunodeficiency Virus Infections: A Review

机译：撒哈拉以南非洲植物在人类免疫缺陷病毒感染管理中的潜力：综述

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摘要

Acquired immunodeficiency syndrome, caused by human immunodeficiency virus (HIV), is a leading cause of mortality and morbidity in Sub-Saharan Africa, particularly in Southern Africa. Phytomedicines are an integral part of African health care. The Southern African flora is composed of at least 23400 taxa. Despite this richness, only a handful of botanical products have been assessed for activities against HIV. This study aimed to summarize the potential of Sub-Saharan African plants, based on their composition and the established bioactivities, as sources of agents to manage HIV symptoms and as retroviral therapy. At least 109 plant species from 42 families and 94 genera that are found in Southern Africa were shown to have potential or actual activities against HIV. Only 12 of these plant species from 6 families and 10 genera were shown to harbour anti-HIV properties. Phytochemicals that include -sitosterols, terpenoids, glycosides, saponins, flavonoids, triterpenoids, tannins and alkaloids, which harbour anti-HIV properties, were found to have a near cosmopolitan presence across the plant families in the region. Bioactivities of multiple phytochemicals are comparable to those for standard allopathic antiretroviral drugs. Research to determine the anti-HIV activities of the identified and other plants, including clinical trials, is long overdue. Copyright (C) 2015 John Wiley & Sons, Ltd.
机译：由人类免疫缺陷病毒（HIV）引起的后天免疫缺陷综合症是撒哈拉以南非洲地区（尤其是南部非洲）死亡率和发病率的主要原因。植物药是非洲卫生保健不可或缺的一部分。南部非洲植物群至少包含23400个分类单元。尽管具有如此丰富的功能，但仅评估了少数几种植物产品的抗HIV活动。这项研究旨在根据其成分和已建立的生物活性，总结撒哈拉以南非洲植物作为治疗HIV症状的媒介和逆转录病毒疗法的潜力。在南部非洲发现的至少42个科目和94属的109种植物具有抗击艾滋病的潜在或实际活动。这些来自6个科和10属的植物中只有12种具有抗HIV特性。已发现该植物化学物质包括-谷甾醇，萜类化合物，糖苷，皂苷，黄酮类化合物，三萜类化合物，丹宁酸和生物碱，它们具有抗HIV特性，在该地区的植物科中具有近乎世界性的存在。多种植物化学物质的生物活性与标准同种异体抗逆转录病毒药物的生物活性相当。确定已鉴定植物和其他植物的抗HIV活性的研究，包括临床试验，早就应该进行。版权所有（C）2015 John Wiley＆Sons，Ltd.

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