Epigenetic reprogramming in mammalian nuclear transfer

LI Shijie; DU Weihua; LI Ning

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Epigenetic reprogramming in mammalian nuclear transfer

机译：哺乳动物核移植中的表观遗传重编程

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Somatic cloning has been succeeded in some species, but the cloning efficiency is very low, which limits the application of the technique in many areas of research and biotechnology. The cloning of mammals by somatic cell nuclear transfer (NT) requires epigenetic reprogramming of the differentiated state of donor cell to a totipotent, embryonic ground state. Accumulating evidence indicates that incomplete or inappropriate epigenetic reprogramming of donor nuclei is likely to be the primary cause of failures in nuclear transfer. This review summarizes the roles of various epigenetic mechanisms, including DNA methylation, histone acetylation, imprinting, X-chromosome inactivation, telomere maintenance and expressions of development-related genes on somatic nuclear transfer.

机译：体细胞克隆已在某些物种中获得成功，但克隆效率非常低，这限制了该技术在许多研究和生物技术领域中的应用。通过体细胞核移植（NT）克隆哺乳动物需要将供体细胞的分化状态表观遗传重编程为全能的胚胎基态。越来越多的证据表明，供体核的不完整或不适当的表观遗传重编程很可能是核移植失败的主要原因。这篇综述总结了各种表观遗传机制的作用，包括DNA甲基化，组蛋白乙酰化，印迹，X染色体失活，端粒维持以及与发育相关的基因在体细胞核转移中的表达。

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《Chinese science bulletin》 |2004年第8期|共6页
作者
LI Shijie; DU Weihua; LI Ning;
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原文格式 PDF
正文语种 eng
中图分类自然科学现状及发展;
关键词
Somatic nuclear transfer; epigenetic reprogramming; DNA methylation; histon acetylation; X-chromosome activation; telomere; imprinting; gene expression;

机译：体细胞核转移;表观遗传重编程;DNA甲基化;组蛋白乙酰化;X染色体活化;端粒;印迹;基因表达;

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1. Intrinsic and extrinsic molecular determinants or modulators for epigenetic remodeling and reprogramming of somatic cell-derived genome in mammalian nuclear-transferred oocytes and resultant embryos [J] . Samiec M., Skrzyszowska M. Polish journal of veterinary sciences . 2018,第1期

机译：哺乳动物核转移的卵母细胞和所得胚胎中细胞源细胞衍生基因组的表观遗传重塑和重新编程的内在和外在的分子测定剂或调节剂
2. Epigenetic reprogramming in mammalian nuclear transfer [J] . LI Shijie, DU Weihua, LI Ning Chinese science bulletin . 2004,第8期

机译：哺乳动物核移植中的表观遗传重编程
3. Epigenetic reprogramming in mammalian nuclear transfer [J] . LI Shijie, DU Weihua, LI Ning Chinese science bulletin . 2004,第8期

机译：哺乳动物核移植中的表观遗传重编程
4. Nuclear cloning, epigenetic reprogramming and cellular differentiation [C] . Rudolf Jaenisch, Konrad Hochedlinger, Kevin Eggan symposium on Stem cells :nuclear reprogramming and therapeutic applications . 2005

机译：核克隆，表观遗传重编程和细胞分化
5. Epigenetic analyses and modulation of nuclear reprogramming. [D] . Park, Joonghoon. 2009

机译：表观遗传分析和核重编程调控。
6. Advance in the Role of Epigenetic Reprogramming in Somatic Cell Nuclear Transfer-Mediated Embryonic Development [O] . Xiaolei Zhang, Shaorong Gao, Xiaoyu Liu 2021

机译：表观遗传重编程在体细胞核转移介导的胚胎发育中的作用进展
7. The effect of mitochondrial genome on architectural remodeling and epigenetic reprogramming of donor cell nuclei in mammalian nuclear transfer-derived embryos [O] . M. Samiec 2005

机译：线粒体基因组对哺乳动物核转移衍生胚胎供体细胞核的建筑重塑和表观遗传重编程的影响

Epigenetic reprogramming in mammalian nuclear transfer

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