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Molecular patterns of avian influenza A viruses

机译：禽流感A病毒的分子模式

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摘要

Avian influenza A viruses could get across the species barrier and be fatal to humans. Highly pathogenic avian influenza H5N1 virus was an example. The mechanism of interspecies transmission is not clear as yet. In this research, the protein sequences of 237 influenza A viruses with different subtypes were transformed into pseudo-signals. The energy features were extracted by the method of wavelet packet decomposition and used for virus classification by the method of hierarchical clustering. The clustering results showed that five patterns existed in avian influenza A viruses, which associated with the phenotype of interspecies transmission, and that avian viruses with patterns C and E could across species barrier and those with patterns A, B and D might not have the abilities. The results could be used to construct an early warning system to predict the transmissibility of avian influenza A viruses to humans.
机译：甲型禽流感病毒可能会越过物种壁垒并对人类致命。高致病性禽流感H5N1病毒就是一个例子。种间传播的机制尚不清楚。在这项研究中，将具有不同亚型的237种甲型流感病毒的蛋白质序列转化为伪信号。通过小波包分解的方法提取能量特征，并通过层次聚类的方法将其用于病毒分类。聚类结果表明，甲型禽流感病毒存在五种模式，与种间传播的表型有关;具有C，E型模式的禽病毒可能跨越物种屏障，而具有A，B，D型模式的病毒可能没有能力。 。该结果可用于构建预警系统，以预测禽流感A病毒对人类的传播能力。

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