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首页> 外文期刊>Wound repair and regeneration: official publication of the Wound Healing Society [and] the European Tissue Repair Society >Reflectance confocal microscopy for the evaluation of acute epidermal wound healing.
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Reflectance confocal microscopy for the evaluation of acute epidermal wound healing.

机译：反射共聚焦显微镜评估急性表皮伤口愈合情况。

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摘要

The dynamic process of wound healing is routinely evaluated by clinical or histological evaluation. Recently, a number of non-invasive imaging techniques have been evaluated for their clinical applicability in dermatology. Among them, reflectance confocal microscopy (RCM) represents a non-invasive imaging technique that allows the in vivo characterization of the skin at near-histological resolution. The aim of this study was to monitor epidermal wound repair using RCM in a model of tissue damage induced by cryosurgery. For this purpose, contact cryosurgery was performed at -32 degrees C for 10 seconds on the volar forearm of five healthy volunteers. Clinical and RCM evaluations were performed at nine consecutive time points. RCM allowed the visualization of edema formation and blood vessel dilatation immediately after cryosurgery, as well as morphologic features of wound repair, including the formation of finger-like protusions of keratinocytes into the wound bed, the appearance of hairpin-like vessels, and inflammatory cells. This pilot study illustrates that RCM represents a promising technique for quasi-real-time monitoring the kinetics of wound repair non-invasively and over time, thus offering new insights into in vivo processes of cutaneous wound repair and angiogenesis, as well as potential effects of topically applied drugs on the process of tissue repair.
机译：伤口愈合的动态过程通常通过临床或组织学评估进行评估。最近，已经评估了许多非侵入性成像技术在皮肤病学中的临床适用性。其中，反射共聚焦显微镜（RCM）代表了一种非侵入性成像技术，可以在接近组织学的分辨率下对皮肤进行体内表征。这项研究的目的是在冷冻手术引起的组织损伤模型中使用RCM监测表皮伤口修复。为此，对五名健康志愿者的掌前臂在-32摄氏度下进行了接触式冷冻手术10秒钟。在连续九个时间点进行临床和RCM评估。 RCM可以在冷冻手术后立即看到水肿形成和血管扩张，以及伤口修复的形态学特征，包括在伤口床上形成角状细胞的手指状突起，发夹状血管和炎症细胞的出现。这项初步研究表明，RCM代表了一种有前途的技术，可用于无创，实时地实时监测伤口修复的动力学，从而为了解皮肤伤口修复和血管生成的体内过程提供了新的见解，并提供了潜在的效果。在组织修复过程中局部应用药物。

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