Somatostatin, somatostatin receptors, and pancreatic cancer.

Li M; Fisher WE; Kim HJ; Wang X; Brunicardi CF; Chen C; Yao Q

首页> 外文期刊>World Journal of Surgery: Official Journal of the Societe Internationale de Chirurgie, Collegium Internationale Chirurgiae Digestivae, and of the International Association of Endocrine Surgeons >Somatostatin, somatostatin receptors, and pancreatic cancer.

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Somatostatin, somatostatin receptors, and pancreatic cancer.

机译：生长抑素，生长抑素受体和胰腺癌。

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Somatostatin may play an important role in the regulation of cancer growth including pancreatic cancer by interaction with somatostatin receptors (SSTRs) on the cell surface. Five SSTRs were cloned, and the function of these SSTRs is addressed in this review. SSTR-2, SSTR-5, and SSTR-1 are thought to play major roles in inhibiting pancreatic cancer growth both in vitro and in vivo. SSTR-3 may be involved in mediating apoptosis, but the role of SSTR-4 is not clear. In most pancreatic cancers, functional SSTRs are absent. Reintroduction of SSTR genes has been shown to inhibit pancreatic cancer growth in cell cultures and animal models.

机译：生长抑素可能通过与细胞表面生长抑素受体（SSTR）相互作用，在调节包括胰腺癌在内的癌症生长中发挥重要作用。克隆了五个SSTR，在本综述中解决了这些SSTR的功能。 SSTR-2，SSTR-5和SSTR-1被认为在体外和体内抑制胰腺癌的生长中起主要作用。 SSTR-3可能参与介导细胞凋亡，但SSTR-4的作用尚不清楚。在大多数胰腺癌中，不存在功能性SSTR。在细胞培养物和动物模型中，SSTR基因的重新引入已显示抑制胰腺癌的生长。

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《World Journal of Surgery: Official Journal of the Societe Internationale de Chirurgie, Collegium Internationale Chirurgiae Digestivae, and of the International Association of Endocrine Surgeons》 |2005年第3期|共4页
作者
Li M; Fisher WE; Kim HJ; Wang X; Brunicardi CF; Chen C; Yao Q;
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正文语种 eng
中图分类外科学;
关键词
Pancreatic Neoplasms; Receptors; Somatostatin; 胰腺肿瘤; 受体; 生长抑素;

机译：Pancreatic Neoplasms;Receptors;Somatostatin;胰腺肿瘤;受体;生长抑素;

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1. Somatostatin, somatostatin receptors, and pancreatic cancer. [J] . Li M, Fisher WE, Kim HJ, World Journal of Surgery: Official Journal of the Societe Internationale de Chirurgie, Collegium Internationale Chirurgiae Digestivae, and of the International Association of Endocrine Surgeons . 2005,第3期

机译：生长抑素，生长抑素受体和胰腺癌。
2. 5-HYDROXYTRYPTAMINE DECREASES SOMATOSTATIN RECEPTORS AND SOMATOSTATIN-RESPONSIVE ADENYLYL CYCLASE IN RAT PANCREATIC ACINAR MEMBRANES [J] . Munozacedo G., Puebla L., Arilla E., Life sciences . 1997,第22期

机译：5-羟色胺减少大鼠胰腺膜中生长抑素受体和生长抑素反应性腺苷酸环化酶
3. Microinjection of exogenous somatostatin in the dorsal vagal complex inhibits pancreatic secretion via somatostatin receptor-2 in rats. [J] . Liao Z, Li ZS, Lu Y, American Journal of Physiology . 2007,第3期

机译：在背迷走神经复合物中显微注射外源生长抑素可抑制大鼠生长激素抑制素受体2的胰腺分泌。
4. Novel Camptothecin Somatostatin Conjugate in Treatment of Tumor Cells Expressing sst2 Receptors [C] . Philip G. Kasprzyk, Ann V. Fiore, Yeelana Shen American Peptide Symposium . 2013

机译：新型Camptothecin Somatostatin缀合物治疗表达SST2受体的肿瘤细胞
5. Specificity of somatostatin receptor and G-protein interactions as characterized by somatostatin receptor subtype specific antibodies. [D] . Gu, Yi-Zhong. 1996

机译：以生长抑素受体亚型特异性抗体为特征的生长抑素受体和G蛋白相互作用的特异性。
6. Down-regulation of pancreatic and duodenal homeobox-1 by somatostatin receptor subtype 5: a novel mechanism for inhibition of cellular proliferation and insulin secretion by somatostatin [O] . Guisheng Zhou, Jim Sinnett-Smith, Shi-He Liu, 2014

机译：生长抑素受体亚型5对胰腺和十二指肠homeobox-1的下调：一种抑制生长抑素的细胞增殖和胰岛素分泌的新机制
7. Somatostatin Inhibits Insulin and Glucagon Secretion via Two Receptor Subtypes: An in Vitro Study of Pancreatic Islets from Somatostatin Receptor 2 Knockout Mice [O] . M. Z. Strowski 2000

机译：生长抑素通过两种受体亚型抑制胰岛素和胰高血糖素分泌：来自生长抑素受体2敲除小鼠的胰岛胰岛的体外研究
8. Biology of Somatostatin and Somatostatin Receptors in Breast Cancer. [R] . Patel, Y. C. 2001

机译：生长抑素和生长抑素受体在乳腺癌中的生物学研究。

Somatostatin, somatostatin receptors, and pancreatic cancer.

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