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首页> 外文期刊>World Journal of Surgery: Official Journal of the Societe Internationale de Chirurgie, Collegium Internationale Chirurgiae Digestivae, and of the International Association of Endocrine Surgeons >Usefulness of thyroglobulin measurement in fine-needle aspiration biopsy specimens for diagnosing cervical lymph node metastasis in patients with papillary thyroid cancer.
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Usefulness of thyroglobulin measurement in fine-needle aspiration biopsy specimens for diagnosing cervical lymph node metastasis in patients with papillary thyroid cancer.

机译：甲状腺球蛋白在细针穿刺活检标本中的诊断对甲状腺乳头状癌患者颈淋巴结转移的诊断有用。

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The diagnosis of lymph node metastasis in patients with papillary thyroid cancer is an important factor when deciding to perform neck dissection at the initial surgery, as well as for evaluating the lymph node swelling after surgery. Ultrasound (US)-guided fine-needle aspiration biopsy cytology (FNAB-C) is the most useful technique for diagnosing lymph node metastasis. Recently, however, measurement of thyroglobulin in the wash-out of the needle (FNAB-Tg) has been proposed for early detection of neck lymph node metastasis in patients with differentiated thyroid cancer. The purpose of this study was to evaluate the usefulness of FNAB-Tg in detecting lymph node metastasis prior to initial or reoperative thyroid surgery. US-guided FNAB-C was performed on 129 enlarged lymph nodes of 111 patients before surgery. All of them were later histologically confirmed to contain metastasis. Immediately after obtaining an FNAB-C specimen, the needle was rinsed with 0.5 ml of normal saline solution, and the wash-out was subjected to measurement of the Tg level (FNAB-Tg). If the FNAB-Tg level was higher than the serum Tg of the patient, we diagnosed the lymph node as positive (metastatic lymph node). FNAB-Tg sensitivity was 81.4%, and FNAB-C sensitivity was 78.0%. Altogether, 4 (36.4%) of 11 cases judged benign positive by the FNAB-Tg measurement. Thyroglobulin measurement in fine-needle aspiration biopsy wash-out is thus a useful technique for diagnosing lymph node metastasis of papillary thyroid cancer.
机译：甲状腺乳头状癌患者的淋巴结转移诊断是决定在初次手术时进行颈部解剖以及评估术后淋巴结肿胀的重要因素。超声（美国）引导的细针穿刺活检细胞学检查（FNAB-C）是诊断淋巴结转移的最有用技术。然而，最近，有人提出了在针头冲洗液中测定甲状腺球蛋白（FNAB-Tg）的方法，以早期发现分化型甲状腺癌患者的颈部淋巴结转移。这项研究的目的是评估FNAB-Tg在甲状腺手术初次或手术前检测淋巴结转移的有用性。术前对111例患者的129个扩大淋巴结进行了US引导的FNAB-C。所有这些均在以后的组织学检查中证实含有转移。获得FNAB-C标本后，立即用0.5 ml生理盐水冲洗针头，并对洗出液进行Tg水平（FNAB-Tg）的测量。如果FNAB-Tg水平高于患者的血清Tg，则我们将淋巴结诊断为阳性（转移性淋巴结）。 FNAB-Tg敏感性为81.4％，FNAB-C敏感性为78.0％。通过FNAB-Tg测定，在11例良性阳性病例中，共有4例（36.4％）。因此，细针穿刺活检冲洗中甲状腺球蛋白的测定是诊断甲状腺乳头状癌淋巴结转移的有用技术。

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