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首页> 外文期刊>World Journal of Surgery: Official Journal of the Societe Internationale de Chirurgie, Collegium Internationale Chirurgiae Digestivae, and of the International Association of Endocrine Surgeons >Value of both WHO and TNM classification systems for patients with pancreatic endocrine tumors: results of a single-center series.
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Value of both WHO and TNM classification systems for patients with pancreatic endocrine tumors: results of a single-center series.

机译：WHO和TNM分类系统对胰腺内分泌肿瘤患者的价值：单中心研究的结果。

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OBJECTIVES: This study was designed to evaluate the clinical relevance of the World Health Organization (WHO) and tumor node metastasis (TNM) classifications in patients affected by pancreatic endocrine tumors. METHODS: Data from 76 consecutive patients with pancreatic endocrine tumors who underwent surgery were analyzed. RESULTS: Well-differentiated tumors were observed more frequently (57.9%) than well or poorly differentiated carcinomas (26.3% and 15.8%, respectively). The TNM stage was I in 27.6%, II in 39.5%, III in 19.7%, and IV in 13.2%. Univariate analysis of disease-specific survival showed that patients with stages I-II had a significantly better survival rate than those with stages III-IV (hazard ratio (HR), 12.46; 95% confidence interval (CI), 1.53-101.32; P = 0.018; HR, 25.74; 95% CI, 3.07-216.07; P = 0.003, respectively). Regarding the WHO classification, poorly differentiated carcinomas had the worst prognosis (HR, 79.13; 95% CI, 9.99-626.60; P < 0.001). Multivariate Cox regression analysis of disease-specific survival showed that the WHO classification is the only independent factors of improved survival: both poorly and well-differentiated carcinomas had an increased risk of death compared with WDTs (HR, 100.42; 95% CI, 12.16-829.40; P < 0.001; HR, 10.73; 95% CI, 1.12-104.17; P = 0.040, respectively). TNM classification and the WHO system are highly correlated (P < 0.001). CONCLUSIONS: TNM stage and the WHO classification seems to be equally reliable, even if TNM classification tends to understage the patients classified using the WHO system.
机译：目的：本研究旨在评估世界卫生组织（WHO）和受胰腺内分泌肿瘤影响的患者的肿瘤淋巴结转移（TNM）分类的临床相关性。方法：对76例接受手术的胰腺内分泌肿瘤患者的数据进行分析。结果：与高分化或低分化癌相比，高分化肿瘤的发生率更高（57.9％）（分别为26.3％和15.8％）。在TNM阶段中，I占27.6％，II占39.5％，III占19.7％，IV占13.2％。对疾病特异性存活率的单因素分析显示，I-II期患者的生存率明显高于III-IV期患者（危险比（HR）为12.46; 95％置信区间（CI）为1.53-101.32; P分别为0.018; HR，25.74; 95％CI，3.07-216.07; P = 0.003。关于WHO分类，低分化癌的预后最差（HR，79.13; 95％CI，9.99-626.60; P <0.001）。对特定疾病生存率的多变量Cox回归分析表明，WHO分类是改善生存率的唯一独立因素：与WDT相比，低分化和高分化癌均具有更高的死亡风险（HR，100.42; 95％CI，12.16- 829.40; P <0.001; HR，10.73; 95％CI，1.12-104.17; P = 0.040）。 TNM分类与WHO系统高度相关（P <0.001）。结论：TNM分期和WHO分类似乎是一样可靠的，即使TNM分类倾向于使使用WHO系统分类的患者处于低位。

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