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Studies on molecular interactions between puerarin and PC liposomes

机译：葛根素与PC脂质体分子相互作用的研究

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Fluorescence emission spectra, FTIR spectra, zeta potential measurements, and ab initio quantum calculation are used to study the interaction between puerarin and membranes composed of egg phosphatidylcholine (PC) liposome. The hydrophobic interactions cause the puerarin molecule to partition into lipid bilayers with its B-ring, and favor the displacement of acid-base equilibrium of puerarin towards the base form. Due to the hydrogen bond formation between the puerarin hydroxyl groups and polar groups of PC molecules on the water/membrane interface, puerarin can easily intercalate into the organized structure of phospholipids and modulate the membrane function. Our results reveal that the liposome membrane integrity is significantly higher comparedwith that of empty liposome.
机译：荧光发射光谱，FTIR光谱，zeta电位测量和从头算量子计算被用来研究葛根素和鸡蛋卵磷脂（PC）脂质体组成的膜之间的相互作用。疏水相互作用导致葛根素分子通过其B环分配到脂质双层中，并促进了葛根素的酸碱平衡向碱形式的位移。由于在水/膜界面上的葛根素羟基和PC分子极性基团之间形成氢键，葛根素可轻松插入磷脂的有组织结构并调节膜功能。我们的结果表明，与空脂质体相比，脂质体膜的完整性显着更高。

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