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首页> 外文期刊>World journal of urology >Adrenal tumours are more predominant in females regardless of their histological subtype: A review
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Adrenal tumours are more predominant in females regardless of their histological subtype: A review

机译：不论其组织学亚型如何，女性的肾上腺肿瘤均占优势

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Objectives: Adrenal tumours are a heterogeneous group of rare tumours. The aim of this article was to critically review gender-specific differences in the incidence, prognosis and symptoms of the different subtypes of adrenal tumours. Methods: Data acquisition regarding gender differences in adrenal tumours was performed using MEDLINE searches with combinations of the following keywords: adrenal tumours, gender, sex differences, adrenocortical carcinoma, pheochromocytoma, incidentaloma, risk factors and genetic aspects. Results: Data are scarce in the literature concerning the effects of gender on adrenal lesions. Although the incidence of most types of tumours (other than breast cancer and other gender-related tumours) is higher in men than in women, evidence suggests that adrenal tumours (i.e. incidentalomas, adrenal carcinomas, oncocytomas and adrenal cysts) are more frequent in women than in men. In addition, female patients have significantly increased numbers of self-reported signs and symptoms of pheochromocytoma than male patients, irrespective of biochemical phenotype and tumour presentation. Relatively little research has been performed examining the reasons for these disparities. However, hormonal interactions involving complex adrenal, endocrine and neurocrine functions together with variations in hormonal receptor sensitivity have been hypothesised to be involved. Conclusion: Gender differences exist in the incidence and symptoms of several subtypes of adrenal tumours. The reasons for these disparities are not well established. In addition to epidemiological data, these results need to be further investigated to better understand the role of genetic and hormonal predispositions in the development, behaviour and aggressiveness of adrenal tumours.
机译：目的：肾上腺肿瘤是稀有肿瘤的异质性组。本文的目的是严格审查不同性别的肾上腺肿瘤的发病率，预后和症状方面的性别差异。方法：使用MEDLINE搜索并结合以下关键词进行有关肾上腺肿瘤性别差异的数据采集：肾上腺肿瘤，性别，性别差异，肾上腺皮质癌，嗜铬细胞瘤，偶发瘤，危险因素和遗传因素。结果：关于性别对肾上腺病变影响的文献资料很少。尽管大多数类型的肿瘤（除了乳腺癌和其他与性别有关的肿瘤）在男性中的发生率都比女性高，但证据表明，女性中肾上腺肿瘤（即偶发瘤，肾上腺癌，肿瘤细胞瘤和肾上腺囊肿）的发生率更高。比男人要多此外，女性患者的嗜铬细胞瘤自我报告症状和体征数量明显多于男性患者，而不论其生化表型和肿瘤表现如何。很少有研究检查这些差异的原因。然而，已假定涉及复杂的肾上腺，内分泌和神经分泌功能的激素相互作用以及激素受体敏感性的变化。结论：几种肾上腺肿瘤亚型的发生率和症状均存在性别差异。这些差异的原因尚不明确。除了流行病学数据外，还需要进一步研究这些结果，以更好地了解遗传和激素易感性在肾上腺肿瘤的发生，行为和侵袭性中的作用。

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