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Dynamics of telomere length in the chicken

机译：鸡端粒长度的动态

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摘要

Telomeres are specialised nucleoprotein end structures of eukaryotic chromosomes and protect and maintain genome integrity from recombination, exonuclease degradation and end-to-end fusion. Because of the end replication problem, telomere length in somatic cells tends to decrease with organismal age. Telomere shortening is known to occur in chicken somatic tissues and correlates with advanced developmental age. However, age is not the only determinant of telomere length in an individual. Several factors at the genetic and epigenetic levels are known to affect telomere length in different ways. Herein, we review several factors that affect telomere length in the chicken. Genetic factors include breed and sex, while the epigenetic factors include environmental and stochastic influences. Age, stocking density and living or housing systems were reviewed as environmental factors pertaining to the habitat of the organism. Factors such as oxidative stress, antioxidants in feed and restriction feeding were the stochastic factors that we reviewed.
机译：端粒是真核染色体的特殊核蛋白末端结构，可保护和维持基因组完整性，防止重组，核酸外切酶降解和端对端融合。由于末端复制问题，体细胞中的端粒长度会随着生物年龄的增长而减少。已知端粒缩短发生在鸡的体细胞组织中，并且与晚期发育年龄有关。然而，年龄并不是个体端粒长度的唯一决定因素。已知在遗传和表观遗传水平上有几种因素以不同的方式影响端粒的长度。本文中，我们回顾了影响鸡端粒长度的几个因素。遗传因素包括品种和性别，而表观遗传因素包括环境和随机影响。年龄，种群密度和生活或住房系统作为与生物栖息地有关的环境因素进行了审查。我们审查了随机因素，例如氧化应激，饲料中的抗氧化剂和限制性饲料。

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