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首页> 外文期刊>Chinese science bulletin >The role of JDP2 in the differentiation of neuroblastoma SH-SY5Y cells
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The role of JDP2 in the differentiation of neuroblastoma SH-SY5Y cells

机译：JDP2在神经母细胞瘤SH-SY5Y细胞分化中的作用

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摘要

c-Jun dimerization protein JDP2 is a member of the AP-1 family that serves as a repressor in gene transcription. To study the role of JDP2 in neuroblastoma cells, we have established a stably transfected SH-SY5Y cell line that carries jdp2 gene. Our results showed that JDP2 could promote neuronal differentiation of SH-SY5Y cells. The SY5Y-JDP2 cells exhibited lower percentage of cells in S phase and retarded growth rate than its parental cells that were accompanied by a higher expression of p21 and an intense reduction of the cyclin D1. In conclusion, the inhibitory role of JDP2 on neuroblastoma cell growth could be critical for the cells to be withdrawn from cell cycle and to proceed differentiation.
机译：c-Jun二聚体蛋白JDP2是AP-1家族的成员，该家族在基因转录中起阻遏作用。为了研究JDP2在神经母细胞瘤细胞中的作用，我们建立了带有jdp2基因的稳定转染的SH-SY5Y细胞系。我们的结果表明，JDP2可以促进SH-SY5Y细胞的神经元分化。与亲本细胞相比，SY5Y-JDP2细胞在S期细胞中的百分比较低，并且生长速度受阻，同时伴随着p21的较高表达和细胞周期蛋白D1的强烈降低。总之，JDP2对神经母细胞瘤细胞生长的抑制作用可能对细胞退出细胞周期并继续分化至关重要。

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