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Prediction of anther-expressed gene regulation in Arabidopsis

机译：拟南芥中花药表达基因调控的预测

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Anther development in Arabidopsis, a popular model plant for plant biology and genetics, is controlled by a complex gene network. Despite the extensive use of this genus for genetic research, little is known about its regulatory network. In this paper, the direct transcriptional regulatory relationships between genes expressed in Arabidopsis anther development were predicted with an integrated bioinformatic method that combines mining of microarray data with promoter analysis. A total of 7710 transcription factor-gene pairs were obtained. The 80 direct regulatory relationships demonstrating the highest confidence were screened from the initial 7710 pairs; three of the 80 were validated by previous experiments. The results indicate that our predicted results were reliable. The regulatory relationships revealed by this research and described in this paper may facilitate further investigation of the molecular mechanisms of anther development. The bioinformatic method used in this work can also be applied to the prediction of gene regulatory relationships in other organisms.
机译：拟南芥（一种流行的植物生物学和遗传学模型植物）的花药发育是由复杂的基因网络控制的。尽管该属广泛用于遗传研究，但对其调控网络知之甚少。在本文中，使用整合的生物信息学方法预测了拟南芥花药发育中表达的基因之间的直接转录调控关系，该方法将微阵列数据的挖掘与启动子分析相结合。总共获得了7710个转录因子-基因对。从最初的7710对中筛选出80个表明最高置信度的直接调节关系。 80个中的三个已通过先前的实验验证。结果表明我们的预测结果是可靠的。这项研究揭示并在本文中描述的调节关系可能有助于进一步研究花药发育的分子机制。在这项工作中使用的生物信息学方法也可以用于预测其他生物中的基因调控关系。

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