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Effects of lanthanum (III) upon cesium (I) uptake by human erythrocytes: a ~(133)Cs NMR study

机译:镧(III)对人红细胞摄取铯(I)的影响:〜(133)Cs NMR研究

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Rare earth compounds would come into the biological systems because of their wide uses, Therefore, it is very important to study their biological effects, The interactions between rare earth ions and the cells have been studied intensively, and reported here are our ~(133)Cs NMR results about the effects of La~(3+) upon C_s~+ uptake by human erythrocytes. The aqueous shift reagents are needed usually in order to increase the transmembrane chemical shift differences in NMR studies of the metal cationtransport across the cellular membrane But, cesium-133 ion is the only alkaline cation whose intra- and extracellular NMR signals separate naturally and clearly without the presence of shift reagents. Besides, cesium ion plays a role similar to that of K~+ in the absence of K~+. Therefore, ~(133)Cs is an ideal probe in NMR studies of the interactions of the rare earth ions with the cells。
机译:稀土化合物由于其用途广泛而进入生物系统,因此,研究其生物学效应非常重要。对稀土离子与细胞之间的相互作用进行了深入研究,是我们的〜(133)。 Cs NMR结果显示La〜(3+)对人红细胞摄取C_s〜+的影响。通常需要水相转移试剂,以增加金属阳离子跨细胞膜传输的NMR研究中跨膜化学移位的差异。但是,铯133离子是唯一的碱性阳离子,其胞内和胞外NMR信号自然而清晰地分离转移试剂的存在。此外,在没有钾离子的情况下,铯离子起着与钾离子相似的作用。因此,〜(133)Cs是NMR研究稀土离子与细胞相互作用的理想探针。

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