• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Chemistry and Physics of Lipids >Virtually same oxidizability of LDL but higher Lp(a) levels in arterial compared to venous plasma
【24h】

Virtually same oxidizability of LDL but higher Lp(a) levels in arterial compared to venous plasma

机译：与静脉血浆相比，LDL的氧化性几乎相同，但动脉中的Lp（a）水平较高

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Plaque formation is confined to the arterial trunk. We assumed that due to the higher aeration of arterial compared to venous blood, higher levels of the atherogenic agent oxidized LDL might be present in arteries, contributing to plaque formation. We aimed to compare (i) the basal oxidative status of LDL in arterial and venous blood and (ii) the susceptibility of arterial and venous LDL to oxidation. The basal oxidative status of LDL was determined by measuring lipid hydroperoxide (LPO) concentrations, plasma levels of auto-antibodies against oxidized LDL, and by measuring oxidation-specific epitopes on LDL particles. The oxidizability of arterial vs. venous LDL (catalyzed by copper) was estimated by monitoring the time-course of conjugated dienes formation. Interestingly, we found the same basal oxidative status of LDL in arterial and venous plasma. LPO concentrations and levels of auto-antibodies against oxidized LDL were similar in arterial and venous plasma and amounts of oxidation-specific epitopes were similar on the respective LDL particles. Moreover, we found similar susceptibilities of arterial and venous LDL to (copper-mediated) oxidation. Lag-times until the onset of conjugated diene formation were slightly shorter in arterial compared to venous LDL in the presence of 5 mu M, but not in the presence of 1 mu M CuCl2. Additionally, we found significantly higher levels of the atherogenic lipoprotein(a) in arterial plasma. We conclude that not higher oxidizability of arterial LDL but higher arterial lipoprotein(a) levels might help to explain why sclerosis is confined to the arterial trunk. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
机译：斑块形成仅限于动脉干。我们假设由于与静脉血相比，较高的动脉通气，动脉中可能存在较高水平的致动脉粥样化物质氧化的LDL，有助于形成斑块。我们旨在比较（i）动脉和静脉血液中LDL的基础氧化状态，以及（ii）动脉和静脉LDL对氧化的敏感性。 LDL的基础氧化状态可通过测量脂质氢过氧化物（LPO）浓度，抗氧化LDL的自身抗体的血浆水平以及测量LDL颗粒上的氧化特异性表位来确定。通过监测共轭二烯形成的时间过程来估算动脉对静脉LDL（由铜催化）的氧化性。有趣的是，我们在动脉和静脉血浆中发现了低密度脂蛋白的基本氧化状态。在动脉和静脉血浆中，LPO的浓度和抗氧化LDL的自身抗体水平相似，并且在各个LDL颗粒上，氧化特异性抗原决定簇的数量相似。此外，我们发现动脉和静脉LDL对（铜介导的）氧化的敏感性相似。与存在5μM的静脉LDL相比，直到存在1μM CuCl 2的静脉LDL相比，直到共轭二烯形成开始的滞后时间略短。此外，我们发现动脉血浆中的动脉粥样硬化脂蛋白（a）水平明显更高。我们得出的结论不是较高的动脉LDL氧化性而是较高的动脉脂蛋白（a）水平可能有助于解释为什么硬化症局限于动脉干。 （C）2014 Elsevier Ireland Ltd.保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号