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The yeast sphingolipid signaling landscape

机译：酵母鞘脂信号传导图景

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摘要

Sphingolipids are recognized as signaling mediators in a growing number of pathways, and represent potential targets to address many diseases. The study of sphingolipid signaling in yeast has created a number of breakthroughs in the field, and has the potential to lead future advances. The aim of this article is to provide an inclusive view of two major frontiers in yeast sphingolipid signaling. In the first section, several key studies in the field of sphingolipidomics are consolidated to create a yeast sphingolipidome that ranks nearly all known sphingolipid species by their level in a resting yeast cell. The second section presents an overview of most known phenotypes identified for sphingolipid gene mutants, pres
机译：鞘脂被认为是越来越多的途径中的信号传导介质，并且代表着解决许多疾病的潜在靶标。酵母中鞘脂信号的研究已经在该领域取得了许多突破，并有望引领未来的发展。本文的目的是提供酵母鞘脂信号传导中两个主要领域的全面观点。在第一部分中，合并了鞘脂系统学领域的几项关键研究，以创建一种酵母鞘脂组，该组根据静息酵母细胞中的水平将几乎所有已知鞘脂种类排列在一起。第二部分概述了为鞘脂基因突变体鉴定的最知名表型

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