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Immune play: defending the liver

机译:免疫游戏:保卫肝脏

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The notable emergence of immunotherapy as an effective and durable anti-tumor treatment strategy is driving intense clinical research into new agents. The recent approval of the first anti-programmed death (PD)-l antibody, pem-brolizumab, by the US FDA in August 2014 for metastatic melanoma, has highlighted the increasingly dominant role that cancer immunotherapy agents play in the oncology therapeutic arsenal. Unpredictably, tumors previously not considered immunogenic have noted encouraging therapeutic responses following treatment with these agents, with a side effect profile which is manageable and less toxic than conventional chemotherapy.
机译:免疫疗法作为一种有效且持久的抗肿瘤治疗策略的显着出现正在推动对新药的大量临床研究。 2014年8月,美国FDA最近批准了首个抗程序性死亡(PD)-1抗体pem-brolizumab用于转移性黑色素瘤,突显了癌症免疫治疗剂在肿瘤治疗药库中的日益重要的作用。不可预测的是,以前未被认为具有免疫原性的肿瘤已经注意到在用这些药物治疗后令人鼓舞的治疗反应,其副作用可控且毒性比常规化学疗法低。

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