Synthesis of enantiomerically pure isotopomers of 2-phenylpropionic acids

Chavda S; Coumbarides GS; Dingjan M; Eames J; Flinn A; Ghilagaber S; Northen J; Yohannes Y

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Synthesis of enantiomerically pure isotopomers of 2-phenylpropionic acids

机译：对映体纯的2-苯基丙酸异构体的合成

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摘要

A series of enantiomerically pure [D, C-13]-labeled isotopomeric 2-phenylpropionic acids were efficiently synthesized using a diastereoselective alkylation and kinetic resolution strategy.

机译：使用非对映选择性烷基化和动力学拆分策略，可以有效地合成一系列对映体纯的[D，C-13]标记的同位素异构体2-苯基丙酸。

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《Chirality: The pharmacological, biological, and chemical consequences of molecular asymmetry》 |2007年第5期|共8页
作者
Chavda S; Coumbarides GS; Dingjan M; Eames J; Flinn A; Ghilagaber S; Northen J; Yohannes Y;
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正文语种 eng
中图分类分子生物学;
关键词
alkylation; chiral; diastereoselective; evans; isotopomers; kinetic resolution; oxazolidinones; profens; 2-phenylpropionic acid; EFFICIENT PARALLEL RESOLUTION; ASYMMETRIC-SYNTHESIS; EVANS OXAZOLIDINONES; CHIRAL AUXILIARY; KINETIC RESOLUTION; AROMATIC-COMPOUNDS; GRIGNARD-REAGENTS; CARBOXYLIC-ACIDS; ALKYLATION; ESTERS;

机译：烷基化;手性;非对映选择性;evans;同位素异构体;动力学拆分;恶唑烷酮;脯氨酸;2-苯基丙酸;高效平行拆分;对称合成;EVANS恶唑烷酮;手性助剂;动力学拆分;芳族化合物;烷基化;酯;

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1. Synthesis of enantiomerically pure isotopomers of 2-phenylpropionic acids [J] . Chavda S, Coumbarides GS, Dingjan M, Chirality: The pharmacological, biological, and chemical consequences of molecular asymmetry . 2007,第5期

机译：对映体纯的2-苯基丙酸异构体的合成
2. SYNTHESIS OF ENANTIOMERICALLY PURE STEREOGENICALLY LABILE 4-ARYL-2-HYDROXYTETRONIC ACIDS FROM ENANTIOMERICALLY PURE SILYL-PROTECTED MANDELALDEHYDES - ACI-REDUCTONE ANALOGUES OF PROPIONIC ACID NONSTEROIDAL ANTI-INFLAMMATORY AGENTS [J] . Hopper AT., Witiak DT. The Journal of Organic Chemistry . 1995,第11期

机译：由对映体纯的甲硅烷基丙二醛-丙酸非甾体类抗炎剂的ACI-还原类似物合成对映体纯的甾体稳定的4-芳基-2-羟基强酸
3. Synthesis of Enantiomerically Pure 3-Aryloxy-2-hydroxy- propanoic Acids, Intermediate Products in the Synthesis of cis-4-Aminochroman-3-ols [J] . Z. A. Bredikhina, A. V. Pashagin, A. V. Kurenkov Russian Journal of Organic Chemistry . 2014,第4期

机译：对映体纯的3-芳氧基-2-羟基丙酸的合成，中间产物是顺式4-氨基苯并三醇的合成
4. Synthesis of enantiomerically pure cyclopropane analogues of proteinogenic amino acids using chiral HPLC [C] . Carlos Cativiela, Ana I.Jimenez, Gema Ballano, European Peptide Symposium . 2002

机译：手性HPLC的蛋白质氨基酸对映体纯环丙烷类似物的合成
5. The design and synthesis of novel chiral Z-nitrones with applications towards the syntheses of enantiomerically pure 4-hydroxy amino acids. [D] . Stanko, John August. 2009

机译：新型手性Z-硝酮的设计和合成及其对映体纯的4-羟基氨基酸的合成应用。
6. Cloning and Characterization of a Novel β-Transaminase from Mesorhizobium sp. Strain LUK: a New Biocatalyst for the Synthesis of Enantiomerically Pure β-Amino Acids [O] . Juhan Kim, Dohyun Kyung, Hyungdon Yun, 2007

机译：介孢子虫新型β-转氨酶的克隆与鉴定LUK菌株：合成对映体纯β氨基酸的新型生物催化剂。
7. Enzymatic catalysis in organic synthesis. Synthesis of enantiomerically pure Ca-substituted a-amino and a-hydroxy acids [O] . Schoemaker, H.E., Boesten, W.H.J., Kaptein, B., 1996

机译：有机合成中的酶催化。对映体纯的Ca取代的α-氨基和α-羟基酸的合成

Synthesis of enantiomerically pure isotopomers of 2-phenylpropionic acids

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