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首页> 外文期刊>Hepato-gastroenterology. >Clinical significance in combined detection of serum pepsinogen I, pepsinogen II and carbohydrate antigen 242 in gastric cancer.
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Clinical significance in combined detection of serum pepsinogen I, pepsinogen II and carbohydrate antigen 242 in gastric cancer.

机译：胃癌中血清胃蛋白酶原I，胃蛋白酶原II和碳水化合物抗原242的联合检测的临床意义。

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摘要

To explore the diagnosis value and clinical significance of combined detection of serum pepsinogen I (PG I), pepsinogen II (PG II), PG I/II and CA242 in patients with stomach diseases.Serum PG I, PG II and CA242 were detected with time-resolved fluoroimmunoassay (TRFIA) method. Serum levers of the four markers in gastric carcinoma were compared with that in chronic superficial gastritis, chronic atrophic gastritis, gastric ulcer and normal controls. The four indices were analyzed to judge their diagnosis value and the relationship with the biology behavior of gastric carcinoma.The serum concentration of PG I in gastric carcinoma and in chronic atrophic gastritis were remarkably lower than that in controls (P < 0.05). The serum concentration of CA242 in gastric carcinoma was significantly higher than that in controls (P < 0.05).To detect the levers of serum PG I, PG II, PG I/II would help to judge the metastasis and prognosis of gastric carcinoma. Combined detection of the four indices could increase the positive rate of diagnosis in gastric carcinoma.
机译：探讨血清胃蛋白酶原I（PG I），胃蛋白酶原II（PG II），PG I / II和CA242联合检测对胃病患者的诊断价值和临床意义。时间分辨荧光免疫分析（TRFIA）方法。比较了胃癌中四种标志物的血清水平与慢性浅表性胃炎，慢性萎缩性胃炎，胃溃疡和正常对照组的血清水平。对这四个指标进行分析，以判断它们的诊断价值以及与胃癌生物学行为的关系。胃癌和慢性萎缩性胃炎中PG I的血清浓度明显低于对照组（P <0.05）。胃癌中CA242的血清浓度明显高于正常人（P <0.05）。检测血清PG I，PG II，PG I / II的水平有助于判断胃癌的转移和预后。四个指标的联合检测可以提高胃癌的诊断阳性率。

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