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首页> 外文期刊>Chemotherapy: International Journal of Experimental and Clinical Chemotherapy >Interaction of cefotetan and the metallo-beta-lactamases produced in Aeromonas spp. and in vitro activity.
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Interaction of cefotetan and the metallo-beta-lactamases produced in Aeromonas spp. and in vitro activity.

机译：头孢替坦与产气单胞菌属的金属-β-内酰胺酶的相互作用。和体外活性。

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摘要

Aeromonas spp. are increasingly being recognized as human pathogens. The presence of metallo-beta-lactamases in these organisms represents a potential problem in antimicrobial therapy. Mechanism-based inactivators of beta-lactamases are used to overcome the resistance of clinical pathogens to beta-lactam antibiotics, but no clinical useful inhibitors of the metallo-beta-lactamases are presently known. Studying the interaction between cefotetan and Aeromonas spp. producing metallo-beta-lactamase activity, we observed that cefotetan behaved as a transient inactivator for both the crude extracts of Aeromonas strains and the purified enzymes from Aeromonas hydrophila AE036 and Aeromonas schubertii MNSA20. The direct hydrolysis of cefotetan showed that it was a poor substrate for both purified enzymes. In view of the minimum inhibitory concentrations, cefotetan shows to be a useful antimicrobial agent against Aeromonas spp. Copyright 2000 S. Karger AG, Basel.
机译：气单胞菌被越来越多地认为是人类病原体。这些生物中金属β-内酰胺酶的存在代表了抗微生物治疗中的潜在问题。 β-内酰胺酶的基于机理的灭活剂用于克服临床病原体对β-内酰胺抗生素的抗性，但是目前尚不知道临床上有用的金属-β-内酰胺酶抑制剂。研究头孢替坦和气单胞菌之间的相互作用。产生金属-β-内酰胺酶活性，我们观察到头孢替坦对气单胞菌菌株的粗提物和嗜水气单胞菌AE036和舒氏气单胞菌MNSA20的纯化酶均起着瞬时灭活剂的作用。头孢替坦的直接水解表明，它是两种纯化酶的不良底物。考虑到最小抑制浓度，头孢替坦显示出是针对气单胞菌属的有用的抗菌剂。版权所有2000 S. Karger AG，巴塞尔。

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