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首页> 外文期刊>Hepatology: Official Journal of the American Association for the Study of Liver Diseases >Should antiviral treatment be extended to patients with chronic hepatitis B and mildly elevated alanine aminotransferase?
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Should antiviral treatment be extended to patients with chronic hepatitis B and mildly elevated alanine aminotransferase?

机译：慢性乙型肝炎和丙氨酸氨基转移酶轻度升高的患者是否应扩大抗病毒治疗？

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摘要

Studies that have focused on patients in the immune-tolerant phase have shown that hepatic inflammation and fibrosis are negligible to mild in most patients with minimal or no progression after 5 years. In one study of 40 patients, 20 had a Metavir fibrosis score of F0, and 20 had a score of F1; 9 had a Metavir activity score of A0,29 had a score of Al, and only 2 had a score of A2.10 In another study of 57 patients, 19 had an Ishak fibrosis score of 0 (range - 0-6), and 38 had stage 1 fibrosis.11 Follow-up biopsies after a mean of 5 years revealed no changes in the fibrosis scores for 42 of 48 patients who remained in the immune-tolerant phase.
机译：专注于免疫耐受期患者的研究表明，大多数患者的肝部炎症和纤维化程度轻微，而5年后无进展或无进展。在一项针对40位患者的研究中，有20位的Metavir纤维化评分为F0，有20位的评分为F1。 9例的Metavir活性评分为A0，29的A1评分，只有2的A2评分。10在另一项针对57例患者的研究中，有19例的Ishak纤维化评分为0（范围-0-6），并且38例为1期纤维化。11平均5年后的随访活检显示48例仍处于免疫耐受期的患者中42例的纤维化评分没有变化。

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