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首页> 外文期刊>Hepatology: Official Journal of the American Association for the Study of Liver Diseases >Identification of metastasis-related microRNAs in hepatocellular carcinoma
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Identification of metastasis-related microRNAs in hepatocellular carcinoma

机译：肝细胞癌转移相关microRNA的鉴定

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摘要

MicroRNAs (miRNAs) have been used as cancer-related biomarkers. Hepatocellular carcinoma (HCC) is an aggressive cancer with a dismal outcome largely due to metastasis and postsurgical recurrence. We investigated whether the expression of certain miRNAs are associated with HCC metastasis. We examined the miRNA expression profiles of 482 cancerous and noncancerous specimens from radical resection of 241 patients with HCC. Using a supervised algorithm and a clinically well-defined cohort of 131 cases, we built a unique 20-miRNA metastasis signature that could significantly predict (P < 0.001) primary HCC tissues with venous metastases from metastasis-free solitary tumors with 10-fold cross-validation. However, significant miRNAs could not be identified from the corresponding noncancerous hepatic tissues. A survival risk prediction analysis revealed that a majority of the metastasis-related miRNAs were associated with survival. Furthermore, the 20-miRNA tumor signature was validated in 110 additional cases as a significant independent predictor of survival (P = 0.009) and was significantly associated with both survival and relapse in 89 cases of early stage HCC (P = 0.022 and 0.002, respectively). These 20 miRNAs may provide a simple profiling method to assist in identifying patients with HCC who are likely to develop metastases/recurrence. In addition, functional analysis of these miRNAs may enhance our biological understanding of HCC metastasis.
机译：MicroRNA（miRNA）已被用作癌症相关的生物标记。肝细胞癌（HCC）是一种侵袭性癌症，其结果令人沮丧的主要原因是转移和术后复发。我们调查了某些miRNA的表达是否与肝癌转移相关。我们检查了241例HCC根治性切除术中482例癌性和非癌性标本的miRNA表达谱。使用监督算法和131例临床上明确定义的队列，我们​​建立了独特的20-miRNA转移特征，可以显着预测（P <0.001）原发性HCC组织的无转移单发肿瘤的静脉转移，其交叉转移是10倍-验证。但是，无法从相应的非癌性肝组织中鉴定出重要的miRNA。生存风险预测分析表明，大多数与转移相关的miRNA与生存相关。此外，在另外110例病例中证实了20-miRNA肿瘤标志物是生存的重要独立预测因子（P = 0.009），并且在89例早期HCC病例中与生存和复发均显着相关（分别为P = 0.022和0.002）。 ）。这20个miRNA可以提供一种简单的分析方法，以帮助鉴定可能发生转移/复发的HCC患者。此外，对这些miRNA的功能分析可能会增强我们对HCC转移的生物学理解。

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