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首页> 外文期刊>Hepatology: Official Journal of the American Association for the Study of Liver Diseases >Metastatic tumor antigen 1 is closely associated with frequent postoperative recurrence and poor survival in patients with hepatocellular carcinoma
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Metastatic tumor antigen 1 is closely associated with frequent postoperative recurrence and poor survival in patients with hepatocellular carcinoma

机译：转移性肿瘤抗原1与肝细胞癌患者术后频繁复发和生存不良密切相关

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Metastatic tumor antigen 1 (MTA1) is known to play a role in angiogenic processes as a stabilizer of hypoxia-inducible factor 1-alpha (HIF1-alpha). In this study, we examined whether overexpression of MTA1 affects the recurrence of hepatocellular carcinoma (HCC) after surgical resection and the survival of the patients. A total of 506 HCC patients who underwent hepatic resection were included in the study. They were followed up for a median of 43 months (range, 1-96 months) after hepatectomy. MTA1 expression levels were determined by the proportion of immunopositive cells (none, all negative; +, < 50%; + +, > 50%). The relationships between MTA1 expression and the HCC histological features, the appearance of recurrent HCC after surgical resection, and the survival of the patients were examined. Eighty-eight cases (17%) of the HCCs were positive for MTA1, although the surrounding liver tissues were all negative for MTA1; 62 cases were + and 26 cases were + +. Increased MTA1 expression levels in HCC were correlated with larger tumors (P = 0.04), perinodal extension (P = 0.03), and microvascular invasion (P = 0.008). Histological differentiation had marginal significance (P = 0.056). However, there was no association between MTA1 expression and age, sex, Child-Pugh class, and capsule invasion of HCC. Interestingly, MTA1 expression levels were significantly greater in hepatitis B virus (HBV)-associated HCC compared with hepatitis C virus (HCV)-associated HCC (P = 0.017). The cumulative recurrence rates of MTA1-positive HCCs were markedly greater than those of MTA1-negative HCCs (P < 0.0001). The cumulative survival rates of patients with MTA1-positive HCCs were significantly shorter than those of patients with MTA1-negative HCCs (P < 0.0001). In conclusion, our data indicate that MTA1 is closely associated with microvascular invasion, frequent postoperative recurrence, and poor survival of HCC patients, especially in those with HBV-associated HCC.
机译：已知转移性肿瘤抗原1（MTA1）在血管生成过程中作为缺氧诱导因子1-alpha（HIF1-alpha）的稳定剂发挥作用。在这项研究中，我们检查了MTA1的过表达是否会影响手术切除后肝细胞癌（HCC）的复发以及患者的存活率。该研究共纳入506例接受肝切除术的HCC患者。肝切除术后对其进行中位随访43个月（范围1-96个月）。 MTA1表达水平由免疫阳性细胞的比例确定（无，均为阴性; +，<50％; ++，> 50％）。检查了MTA1表达与HCC组织学特征，手术切除后复发性HCC的出现以及患者生存之间的关系。尽管周围的肝组织均对MTA1阴性，但88例HCC的MCC1阳性（17％）。 62例为+，26例为+ +。肝癌中MTA1表达水平升高与更大的肿瘤（P = 0.04），淋巴结扩展（P = 0.03）和微血管浸润（P = 0.008）相关。组织学差异具有边际意义（P = 0.056）。但是，MTA1的表达与年龄，性别，Child-Pugh类别和HCC的胶囊浸润之间没有关联。有趣的是，与丙型肝炎病毒（HCV）相关的HCC相比，乙型肝炎病毒（HBV）相关的HCC中MTA1表达水平显着更高（P = 0.017）。 MTA1阳性HCC的累积复发率显着高于MTA1阴性HCC的累积复发率（P <0.0001）。 MTA1阳性肝癌患者的累积生存率显着短于MTA1阴性肝癌患者（P <0.0001）。总之，我们的数据表明，MTA1与HCC患者的微血管侵袭，频繁的术后复发以及较差的生存密切相关，尤其是在那些与HBV相关的HCC患者中。

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