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首页> 外文期刊>Hepatology: Official Journal of the American Association for the Study of Liver Diseases >Treatment response in patients with autoimmune hepatitis.
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Treatment response in patients with autoimmune hepatitis.

机译：自身免疫性肝炎患者的治疗反应。

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We congratulate Manns and colleagues1 on their comprehensive review of and guidelines for the treatment of autoimmune hepatitis (AIH). The importance of complete biochemical remission, which is defined as normalization of aminotransferases and immunoglob-ulin G (IgG)/gamma-globulins, is underlined as the ideal treatment endpoint and as the goal of initial therapy. Notably, normalization of only aminotransferases is still being used as a definition of biochemical remission. We and others have previously shown that elevated levels of aminotransferases, IgG/gamma-globulins, or both may indicate histological activity, and this in turn indicates an increased risk of disease relapse and progression. ' Therefore, complete biochemical remission as a surrogate parameter for histological remission should be achieved with as few side effects as possible. In addition, recent studies have suggested that a fast response to treatment may be associated with a better outcome.
机译：我们祝贺曼斯及其同事1对自身免疫性肝炎（AIH）的治疗进行了全面的审查并提出了指南。强调完全生化缓解的重要性被定义为理想的治疗终点和初始治疗的目标，完全缓解是指氨基转移酶和免疫球蛋白G（IgG）/γ-球蛋白的正常化。值得注意的是，仅氨基转移酶的标准化仍被用作生化缓解的定义。我们和其他人以前已经表明，转氨酶，IgG /γ-球蛋白或两者的水平升高可能表明组织学活动，而这又表明疾病复发和进展的风险增加。因此，应实现完全的生化缓解作为组织学缓解的替代参数，并尽可能减少副作用。此外，最近的研究表明对治疗的快速反应可能会带来更好的预后。

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